Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19
R Alon, M Sportiello, S Kozlovski, A Kumar… - Nature Reviews …, 2021 - nature.com
… -CoV-2 is not efficiently cleared from the respiratory system, and in … clearance of influenza
virus from the lung has been shown to depend on migratory langerin-positive CD103 + CD11b …
virus from the lung has been shown to depend on migratory langerin-positive CD103 + CD11b …
Lung dendritic cells migrate to the spleen to prime long-lived TCF1hi memory CD8+ T cell precursors after influenza infection
MM Jenkins, H Bachus, D Botta, MD Schultz… - Science …, 2021 - science.org
… and the med-LN were a mix of cDC1 (XCR1 hi CD103 + CD11b … hypothesized that smDCs
were lung mDCs that, after migrating … into the med-LN is CCR7 dependent (7, 36, 37), we first …
were lung mDCs that, after migrating … into the med-LN is CCR7 dependent (7, 36, 37), we first …
Host protective immune responses against influenza A virus infection
… cell-mediated viral clearance during influenza virus infection. … Following influenza infection,
lung-migratory cDCs take up … demonstrated that IRF4-dependent DCs that express CD11b + …
lung-migratory cDCs take up … demonstrated that IRF4-dependent DCs that express CD11b + …
Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity
… We observed that CD11b − and CD11b lo pre-cDCs generated all cDC subsets, including
inf… ligands in lung tissue that would oppose such migration. As for possible CCR2-dependent …
inf… ligands in lung tissue that would oppose such migration. As for possible CCR2-dependent …
Human influenza virus infection elicits distinct patterns of monocyte and dendritic cell mobilization in blood and the nasopharynx
… In patients with other respiratory virus infections, we observed … and DCs vary in distribution
and function, depending on … cells during IAV infection suggests migration of mature cells to the …
and function, depending on … cells during IAV infection suggests migration of mature cells to the …
Trafficking and retention of protein antigens across systems and immune cell types
TA Doan, T Forward, BAJ Tamburini - Cellular and Molecular Life Sciences, 2022 - Springer
… Antigens that pass through the M cells at intestinal or lung … deep cervical LN for clearance
will improve our understanding of … Within each cDC subset there are both migratory and spleen/…
will improve our understanding of … Within each cDC subset there are both migratory and spleen/…
Cigarette smoke affects dendritic cell populations, epithelial barrier function, and the immune response to viral infection with H1N1
O Danov, M Wolff, S Bartel, S Böhlen… - Frontiers in …, 2020 - frontiersin.org
… Influenza virus is a common human respiratory pathogen … CD103 + and CD11b + migratory
cDCs were shown to … unchanged, CD11b + cDCs showed a dose dependent increase in …
cDCs were shown to … unchanged, CD11b + cDCs showed a dose dependent increase in …
Inflammatory type 2 cDCs acquire features of cDC1s and macrophages to orchestrate immunity to respiratory virus infection
C Bosteels, K Neyt, M Vanheerswynghels… - Immunity, 2020 - cell.com
… of respiratory viral infection, we found that lung cDC2s … -dependent maturation module,
and acquired antigens via convalescent serum and Fc receptors. Because hybrid inf-cDC2s are …
and acquired antigens via convalescent serum and Fc receptors. Because hybrid inf-cDC2s are …
Antigen presentation in the lung
T Kawasaki, M Ikegawa, T Kawai - Frontiers in immunology, 2022 - frontiersin.org
… lymph nodes, and lung cDC2s are less migratory than cDC1s (… , there are conflicting reports
on how moDCs and CD11b + … depending on the pathogen infection, and further studies are …
on how moDCs and CD11b + … depending on the pathogen infection, and further studies are …
Memory T cell dynamics in the lung during influenza virus infection
A Pizzolla, LM Wakim - The Journal of Immunology, 2019 - journals.aai.org
… , whereas the CD11b + DC subset is the dominant APC at later time points (28). In addition to
lung-migratory DCs, LN… on migratory langerin+CD11b- but not plasmacytoid dendritic cells. …
lung-migratory DCs, LN… on migratory langerin+CD11b- but not plasmacytoid dendritic cells. …