… Experimental trial participants are not only an inherently poor … potential differences between
experimental and observational cohorts may contribute to poor replicability, we compared …

… electronic health records and other health care transaction systems as a potential source of
medical … In this study of US-based clinical trials with human participants that were published …

… Of 6 potential responses, participants who chose “extremely … after enrollment and between
participants qualifying on the … , highlighting the differences between anatomic evidence of …

… were initially deemed eligible for trial participation. Further, … was used, using the mean of
the difference between study … the potential upper bound on the trial participation estimate, …

… clinical trial enterprise, including the opportunity to run trials … A fully digital trial will enable
access for potential participants … difficulties 18 and overly restrictive eligibility criteria 19 . The …

… opportunities for trial participation for several thousand patients with … potential improvements
in trial participation rates compared with removing all major comorbidity-related eligibility …

… and masking Eligible patients were identified using an acute … at the patient level, allowing
for providers potentially to learn … the research to individual study participants, but the results of …

… the potential for clinical effect—conferred by clinical decision … and studies in which fewer
than half of participants were … bias (systematic differences between groups with respect to the …

… Across all trials, we observed a substantial difference between the median age of trial
participants and the population … A potential contributing factor could be that industry-funded …

… Eligible participants were hospitalized patients with severe … Patients were not eligible if they
had been treated with therapies … to the potential rapid deterioration of patients’ clinical status …