… clinical studies have been conducted with three different upstream prenylation inhibitors,
including lonafarnib, pravastatin… (18) and therefore inhibits progerin farnesylation. FTIs have …

… farnesyltransferase to prevent farnesylation and subsequent … will provide lonafarnib for
ongoing clinical trials and expanded … therefore treatment with pravastatin and zoledronic acid was …

… the effect of farnesylation inhibition on bone … pravastatin) and bisphosphonates (zoledronic
acid) have been tested in combination with lonafarnib in mouse models and in clinical trials …

… clinical trials are likely to evaluate the efficacy of lonafarnib in … with pravastatin and zoledronate
compared with lonafarnib … different consequences of inhibiting progerin farnesylation and …

… of farnesylated progerin. Among the different FTIs showing high efficacy in the inhibition of
FTase in vivo, lonafarnib (… therapy clinical trial in which lonafarnib, pravastatin, and zoledronic …

… acid have been used in clinical trials to target the mevalonate … trial was a three drug
combination of lonafarnib, pravastatin … In this study we found that FTI, pravastatin and zoledronic …

… A Phase II clinical trial using the FTI lonafarnib began in May … Pravastatin is traded as
Pravachol or Selektine and it is … toxicity profiles of lonafarnib and zoledronic acid . Generally, …

… FTase inhibition. An in vivo study also confirmed that RhoB includes the farnesylated and …
A recent meta-analysis with 13 randomized controlled trials reported the protective effect of …

… Clinical trial of the protein farnesylation inhibitors lonafarnib, pravastatin, and zoledronic
acid in children with Hutchinson-Gilford progeria syndrome. Circulation, 134(2), pp.114-125. 8. …

… Impact of farnesylation inhibitors on survival in Hutchinson- Gilford progeria syndrome. …
Clinical trial of the protein farnesylation inhibitors lonafarnib, pravastatin, and zoledronic acid in …