The translational landscape of human vascular smooth muscle cells identifies novel short open reading frame-encoded peptide regulators for phenotype alteration

K Li, B Li, D Zhang, T Du, H Zhou, G Dai… - Cardiovascular …, 2023 - academic.oup.com
… and cloned into pCFH-3×FLAG or phage-6tag vector. A mutant plasmid was generated by …
differentially translating RNA transcripts in this study regulated the alteration VSMC phenotype

Nuclear control of vascular smooth muscle cell plasticity during vascular remodeling

IA Ahmed, M Liu, D Gomez - The American Journal of Pathology, 2024 - Elsevier
… role in regulating SMC functions and phenotypic transitions during vascular remodeling
and … behaviors of SMCs that contribute to the etiology of cardiovascular diseases differently. …

Genetic regulation of atherosclerosis-relevant phenotypes in human vascular smooth muscle cells

R Aherrahrou, L Guo, VP Nagraj, A Aguhob… - Circulation …, 2020 - Am Heart Assoc
… Cells isolated from each individual responded differently to cytokine stimulation. For … It is
also possible that more proliferative SMC clones in the isolated cell population have gained …

Transcriptional regulation of vascular smooth muscle cell proliferation, differentiation and senescence: novel targets for therapy

LM Khachigian, BL Black, P Ferdinandy… - Vascular …, 2022 - Elsevier
regulatory mechanisms governing SMC phenotypicdifferentially expressed in murine and
human atherosclerotic lesions [90] and undergoes phosphorylation at Ser26, which regulates

Vascular smooth muscle

LL Hilenski, K Griendling - Vascular Medicine: A Companion to …, 2019 - books.google.com
… –like contractile phenotype because conversion of cells to a VSMC… genes. 58 These
differential pathways provide a switch in which SRF target genes are differentially regulated through

[PDF][PDF] H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity

M Liu, C Espinosa-Diez, S Mahan, M Du, AT Nguyen… - Developmental cell, 2021 - cell.com
Vascular smooth muscle cells (SMCs) are specialized contractile cells that retain phenotypic
… (A) Volcano plot representing genes differentially expressed in Myocd-LSD1 versus Myocd-…

[PDF][PDF] Smooth muscle cell reprogramming in aortic aneurysms

PY Chen, L Qin, G Li, J Malagon-Lopez, Z Wang… - Cell stem cell, 2020 - cell.com
… À/À phenotype, we tested the consequence of the loss of … in the genome differentially regulating
gene expression, as shown … (G) TGFbR2iSMC-Apoe mice vascular smooth muscle cells (…

Mechanisms of vascular smooth muscle cell investment and phenotypic diversification in vascular diseases

MD Worssam, HF Jørgensen - Biochemical Society Transactions, 2021 - portlandpress.com
… VSMC-derived cells from the same clone can adopt diverse phenotypes. Studies harnessing
the … cells stochastically express one of multiple differently coloured reporter proteins that are …

[HTML][HTML] Smooth muscle cells in atherosclerosis: clones but not carbon copies

C Espinosa-Diez, V Mandi, M Du, M Liu, D Gomez - JVS-Vascular Science, 2021 - Elsevier
… Our knowledge of the contribution of vascular smooth muscle … and phenotypic characterization
of SMC populations within the … differently designed and performed on different vascular

Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis

RC Wirka, D Wagh, DT Paik, M Pjanic, T Nguyen… - Nature medicine, 2019 - nature.com
… stimuli, vascular smooth muscle cells (SMCs… differentially regulated genes between the
phenotypically modulated SMCs and contractile SMCs also showed strong upregulation of genes