A Re-Evaluation of the Relationship between Morphology and Pathogenicity in Candida Species

D Kadosh, V Mundodi - Journal of Fungi, 2020 - mdpi.com
… all Candida species can grow in all three morphologies, and the proportion of cells that grow
in a particular morphology can vary among Candida speciesyeast morphology, whereas C. …

[HTML][HTML] Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infection

P Pais, M Galocha, R Viana, M Cavalheiro… - Microbial Cell, 2019 - ncbi.nlm.nih.gov
… several isolates, which suggests a co-evolution between virulence and resistance. Moreover,
… isolates recovered from cystic fibrosis patients also pointed to morphological changes as a …

Evolution of drug-resistant and virulent small colonies in phenotypically diverse populations of the human fungal pathogen Candida glabrata

SJN Duxbury, S Bates… - Proceedings of the …, 2020 - royalsocietypublishing.org
Candida glabrata is a pathogen of clear clinical importance as it is the second most commonly
isolated Candida species in … At the first glance, the small colony morphology and lower …

Systems biology of host-Candida interactions: understanding how we shape each other

A Hodgins-Davis, TR O'Meara - Current opinion in microbiology, 2020 - Elsevier
… Here we review recent literature elucidating Candida albicans interactions with host … the
importance of the glyoxylate cycle and metabolic plasticity for virulence [36,37]; this work shows …

Emergence and evolution of virulence in human pathogenic fungi

S Siscar-Lewin, B Hube, S Brunke - Trends in microbiology, 2022 - cell.com
… In Candida albicans and related species, the peptide toxin candidalysin may be under selective
pressure due to its virulence and … For millions of years both groups have coevolved while …

The yeast–human coevolution: Fungal transition from passengers, colonizers, and invaders

S Nenciarini, S Renzi, M di Paola… - WIREs Mechanisms …, 2024 - Wiley Online Library
… Immunomodulation by a low-virulence, agerminative variant of Candida albicans. Further
evidence for … Candida albicans morphology and dendritic cell subsets determine T helper cell …

The evolving species concepts used for yeasts: from phenotypes and genomes to speciation networks

T Boekhout, MC Aime, D Begerow, T Gabaldón… - Fungal diversity, 2021 - Springer
Yeast species have been recognized for decades based on phenotypic properties, including
colony and cellular morphologies… to distinguish and compare yeast species when Phaff and …

[HTML][HTML] Immunosurveillance of Candida albicans commensalism by the adaptive immune system

M Swidergall, S LeibundGut-Landmann - Mucosal immunology, 2022 - Elsevier
albicans virulence and immunogenicity are largely … albicans and its mammalian host shape
the outcome of their … albicans has coevolved with humans for at least 2,000 years132, that …

Pathogenesis and virulence of Candida albicans

JP Lopes, MS Lionakis - Virulence, 2022 - Taylor & Francis
Candida albicans is a commensal yeast fungus of the human … with different yeast-like or
filament-like morphologies and … albicans is its ability to change morphology to and from the …

From Jekyll to Hyde: The Yeast–Hyphal Transition of Candida albicans

EWL Chow, LM Pang, Y Wang - Pathogens, 2021 - mdpi.com
albicans to undergo a reversible morphological transition from yeast to filamentous forms
is a well-established virulent trait. Over the past few decades, a significant amount of research …