… factors related to this sexual dimorphism remains to be unraveled… brains, only 5.4% of the
genes were significantly altered … accelerated cognitive deficit and brain injury in 3xTg-AD mice […

… , cognitive, and behavioral effects of neonatal handling in … of male and female 3xTg-AD
mice in social nesting under … activity, but not the modification of vertical exploratory activity, …

… Cognitive abilities showed a sex dimorphism in young and old … on tests of mental rotation
of spatial stimuli [12, 13] compared … alterations early than the previously used 3xTgAD mice. …

… In rodents, early postnatal stimulation [neonatal handling (NH… as non-cognitive and cognitive
functions-emotional and anxiety-… and taking into consideration sexual dimorphism. It also …

… and neurochemical alterations associated with AD has … and Aβ 1-42 production was also
investigated in 3xTgAD mice, … effects against AD-related neuropathology and cognitive …

… the impact of long-term isolation in male 3xTg-AD mice … that of chronically psycho-stimulated
3xTg-AD mice (68), suggests … of the disease where behavioral alterations disrupt cognitive …

… Further, the TgF344-AD rat model yielded more consistent cognitive and … of this system could
promote psychological well-being (eg, … modulation by neonatal handling. Behav. Brain Res. …

… exposures of neonatal and old mice to Iso distinctly altered … EPSPs recorded at various
inter-stimulus intervals (ISI) on … For example, cognitive deficits noted in young 3xTg-AD mice …

… cognitive symptoms including memory and navigational impairments 5,6 . In fact, one of the
earliest cognitive … For these low responding mice, we assessed stimulation responsiveness …

… Preclinical studies in Alzheimer's disease (AD) often rely on … for novelty effects associated
with the visual stimulus, trials were … It is possible that extensive handling and habituation during …