… Individual activity modification such as reducing the time … Other evidences of the effect
of Al on cognitive function are … astrocytes of 3xTg-AD mice. On examination of the ten-month-old …

… altered in AD, it is possible that this dysregulation may contribute to many neuropathological
dysfunctions, as well as the hallmark of AD, progressive cognitive … and emotional functioning…

… in Mild Cognitive Impairment (MCI) and Alzheimer disease (AD). … and/or alterations in
neurogenesis. NR2B expression is … Figure 1 APP processing and tau protein role in microtubules …

… a sexually dimorphic structure involved in emotional respons… methylation and histone
modifications that impact the likelihood … Sex differences in βamyloid accumulation in 3xTg-AD …

… little effect of IL- 34 was observed in male 3x-Tg-AD mice indicating that IL-34 promotes sex…
isolated from bone marrow of young female and male 3x-Tg-AD mice. The changes of mRNA …

… Prenatal ethanol exposure results in an earlier onset of spatial memory deficits in 3xTg-AD
mice, as … In the following sections, I will describe the clinical data characterizing alterations to …

… We then summarize the latest findings from genetic studies of human brain disorders, focusing
on the role of human clock gene variants in these diseases. Lastly, we discuss the impact …

… development through examining alterations in morphology and … other disease pathology
that may lead additionally to cognitive … Recent research in 3xTg-AD mice also demonstrated a …

… The 3xTg AD mouse model, which was used for the current work, displays key features …
cognitive stimulation or problem-solving may provide a stronger cognitive benefit and a better …

… impaired process motility compared to microglia in young Tg mice (192). Microglial accumulation
and … Also, 3xTgAD mice subjected to chronic mild social stress showed an increase in …