KCNE Regulation of KCNQ Channels

GW Abbott - … Transporters and Ion Channels: Ion Channels and …, 2020 - Springer
… of KCNQ1KCNE and other Kv-KCNE channel complexes. … KCNQ1 α subunit was a surprise
made possible by mouse genetics. … further down the digestive tract; in the normal intestine, …

[HTML][HTML] The KCNE2 potassium channel β subunit is required for normal lung function and resilience to ischemia and reperfusion injury

L Zhou, C Köhncke, Z Hu, TK Roepke… - The FASEB …, 2019 - ncbi.nlm.nih.gov
… of potassium channel α subunits Kcnq1 and … colocalized and coimmunoprecipitated with
Kcnq1 in mouse lungs, suggesting the formation of pulmonary Kcnq1-Kcne2 potassium channel

Hormonal signaling actions on Kv7. 1 (KCNQ1) channels

E Thompson, J Eldstrom… - Annual Review of …, 2021 - annualreviews.org
… are expressed in the heart, inner ear, kidney, lung, and gastrointestinal tract. Kv7.2–7.5 are
… in both human and mouse gastric mucosa and has also been shown to colocalize with the H …

Potassium channels in intestinal epithelial cells and their pharmacological modulation: a systematic review

D Cosme, MM Estevinho, F Rieder… - American Journal of …, 2021 - journals.physiology.org
… and characteristics of the KCs found in the gastrointestinal tract are summarized in Table 1.
intestine and colon of mice NB, immunofluorescence KCNQ1 and KCNE3 are colocalized in …

[HTML][HTML] The Multifunctional Role of KCNE2: From Cardiac Arrhythmia to Multisystem Disorders

M Song, Y Zhuge, Y Tu, J Liu, W Liu - Cells, 2024 - mdpi.com
… β-subunits, are unable to form ion channels on their own. However, they play a role in regulating
the α-subunits of various potassium channel … The knockdown of KCNE2 in mice disrupts …

[HTML][HTML] Expression alteration and dysfunction of ion channels/transporters in the parietal cells induces gastric diffused mucosal injury

Y Zhao, Z Deng, Z Ma, M Zhang, H Wang, B Tuo… - Biomedicine & …, 2022 - Elsevier
… When the gastrointestinal tract is injured, TFF peptides … epithelial [49] and colocalizes with
the proton pump and in … -2 -/- mice was obviously reduced compared with that in WT mice, and …

Control of biophysical and pharmacological properties of potassium channels by ancillary subunits

GW Abbott - Pharmacology of Potassium Channels, 2021 - Springer
… the Kcne2 and Kcne3 genes in mice, we showed that in the … for KCNQ1-KCNE3 in the lower
digestive tract). KCNE … pharmacology of the different KCNQ1-KCNE complexes could 1 day …

Kv7 channels and excitability disorders

F Jones, N Gamper, H Gao - Pharmacology of Potassium Channels, 2021 - Springer
… The KvLQT1 gene predicted to code for a K + channel subunit orthologous to the Shaker K
+ channel with predicted 6 membrane-spanning domains (S1-S6), a voltage sensor residing …

[PDF][PDF] Physiological Reviews Review Article

AC Engevik, I Kaji, JR Goldenring - Physiol Rev, 2020 - scholar.archive.org
… in different types of cells in the gastrointestinal tract (326). Inhibitory … , are colocalized with
ghrelin in murine stomach. Bitter … subunit KCNE2 are proposed to form a luminal K channel (85…

Intestinal secretory mechanisms and diarrhea

SJ Keely, KE Barrett - … Gastrointestinal and Liver Physiology, 2022 - journals.physiology.org
The gastrointestinal system deals with … mice suggest that TMEM16A may be an important
pathway for Cl − secretion in this species (20), studies of human intestine indicate the channel