The role of the gut microbiome in colonization resistance and recurrent Clostridioides difficile infection

AM Seekatz, N Safdar… - Therapeutic Advances in …, 2022 - journals.sagepub.com
… and functional dynamics between different intestinal bacterial phyla may … the gut microbiome
that influence colonization resistance can aid in the development of innovative microbiota-…

Gut microbiota and colonization resistance against bacterial enteric infection

QR Ducarmon, RD Zwittink, BVH Hornung… - Microbiology and …, 2019 - Am Soc Microbiol
… the gut microbiota can mediate colonization resistance against … how bacterial enteropathogens
can overcome this resistance. … resistance to Clostridium difficile. Nature 517:205–208. …

Gut Microbiota Composition Associated with Clostridioides difficile Colonization and Infection

E Martinez, B Taminiau, C Rodriguez, G Daube - Pathogens, 2022 - mdpi.com
gut microbiota and the development of CDI. The secondary aim is to provide more information
on why some people colonized with toxigenic C. … gut microbiota to decrease colonization

Developing Gut Microbiota Exerts Colonisation Resistance to Clostridium (syn. Clostridioides) difficile in Piglets

Ł Grześkowiak, TH Dadi, J Zentek, W Vahjen - Microorganisms, 2019 - mdpi.com
difficile counts in suckling piglets. This study showed that gut microbiota seems to set
conditions for colonisation resistance against C. …

Contribution of Inhibitory Metabolites and Competition for Nutrients to Colonization Resistance against Clostridioides difficile by Commensal Clostridium

AD Reed, CM Theriot - Microorganisms, 2021 - mdpi.com
… The use of antibiotics, including vancomycin, is a significant risk factor for CDI due to its
ability to alter the gut microbiota, resulting in a loss of colonization resistance against …

Gut Microbiota and Clostridium difficile: What We Know and the New Frontiers

…, F Rosa, F Manca, G Pignataro, C Zanza… - International Journal of …, 2022 - mdpi.com
Clostridium difficile is a spore-forming … colonization to fearsome complications such as
the onset of toxic megacolon. The relationship between gut microbiota and Clostridium difficile

Mechanisms of Colonization Resistance Against Clostridioides difficile

CM Pike, CM Theriot - The Journal of Infectious Diseases, 2021 - academic.oup.com
… of several microbiota-mediated mechanisms of colonization resistance against C difficile. …
Bile acid 7alphadehydroxylating gut bacteria secrete antibiotics that inhibit Clostridium difficile: …

Clostridium butyricum enhances colonization resistance against Clostridioides difficile by metabolic and immune modulation

M Hagihara, T Ariyoshi, Y Kuroki, S Eguchi… - Scientific Reports, 2021 - nature.com
… host and gut microbiome during CDI. This study revealed two novel gut microbiome and colon
… First, CBM 588 modulation of the gut microbiome resulted in a reduction of gut succinate …

Insights into the Role of Human Gut Microbiota in Clostridioides difficile Infection

M Kachrimanidou, E Tsintarakis - Microorganisms, 2020 - mdpi.com
… use, which disrupts the normal gut microbiota by altering its composition and the gut’s
metabolic functions, leading to the loss of colonization resistance and subsequent CDI. Data from …

Intestinal inflammation and altered gut microbiota associated with inflammatory bowel disease render mice susceptible to Clostridioides difficile colonization and …

L Abernathy-Close, MR Barron, JM George… - Mbio, 2021 - Am Soc Microbiol
… , both of which can diminish colonization resistance to C. … Our results demonstrate that
loss of colonization resistance against C. difficile is not due solely to the changes in microbiota