… More than 75% of patients with hypertension require two or more medications to achieve
BP goal. Therefore, early combination therapy is better than sequential monotherapy.[ 7 ] A …

… combination treatment or monotherapy vs. placebo, no-… judged in terms of sequence generation
and allocation concealment … BP in the high normal BP range or above, a BP reduction is …

… In the STRATHE trial [23] , a low-dose ACEI-thiazide combination therapy compared with
sequential monotherapy and stepped-care therapy produced superior BP control without …

… of combination drug treatment, despite evidence of its superior … the treatment of hypertension
of the drug combination strategy, … use of the sequential monotherapy strategy may represent …

… Prevention and Treatment of Hypertension with Algorithm-based Therapy (PATHWAY)…
Combination therapy is superior to sequential monotherapy for the initial treatment of hypertension…

… -dose combination (62%) compared with sequential monotherapy (49%, P=0.02) or stepped-…
Although initial treatment with dual drug therapy is superior to other treatment strategies in …

… year, ≈40% of patients with hypertension may stop their initial drug treatment. In addition,
≈10% of … ABPM can also detect nocturnal hypertension, 72 which is superior to daytime BP in …

… with dosage titration and sequential addition of other agents if … with stage 1 hypertension
(140/90 mmHg and above) and with … BP decrease in response to initial combination therapy. …

… suggest that combination therapy is superior to monotherapy … and sequential combination
therapy as first-line treatment, some … combined therapy should be used as an initial therapeutic …

… Blood pressure measurements were obtained in two consecutive … (iii) treatment with
monotherapy antihypertensive regimen instead of … was associated with poor control of …