… Tau, the protein product of the MAPT gene, and TDP-43, the … Rarely (∼10%), other proteins
are found in the inclusion … protein 106B (TMEM106B) gene (7p21.3). Replication analysis …

… Therefore, specifically analyzing the pathologic inclusion … did not show overlap with TDP-43
inclusions, but revealed irregular … as promising strategy for TDP-43 related disease [122]. …

… and TDP-43-negative neuronal cytoplasmic inclusions in … in the TDP-43 protein is based
on the fact that TDP-43 regulates … A possible locus in the 7p21 chromosome, containing the …

… not meet criteria for frontotemporal lobar degeneration (FTLD)… of TDP-43 immunoreactive
neuronal cytoplasmic inclusions, … showed that TDP-43 immunoreactivity was associated with …

… gene variants can alter risk for Tau or TDP-43 pathologies, … can influence TDP-43 to form
pathologic inclusions. One … SNPs on chromosome 7p21.3 that were associated with FTLD-…

… (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-… Common
variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions…

… Polymorphisms in TMEM106B, a gene on chromosome 7p21.… clinical outcomes in
frontotemporal lobar degeneration (FTLD) … inclusions, we failed to observe any neurons with …

… inclusions are present in 45% of FTLD cases, MAPT variants … diagnosed TDP-43 cases and
GRN pathogenic variant … -wide significance all within chromosome 7p21, which includes the …

… -associated proteins such as TDP-43 and FUS. However, it remains unclear whether rare
variants in … analyses in pathologically proven frontotemporal lobar degeneration (FTLD) due to …

… Common variants at 7p21 are associated with frontotemporal lobar degeneration with
TDP-43 inclusions. Nat Genet. 2010;42(3):234–9 (First study to map the genetic architecture of …