Identification of novel non-homologous drug targets against Acinetobacter baumannii using subtractive genomics and comparative metabolic pathway analysis

H Kaur, M Kalia, N Taneja - Microbial Pathogenesis, 2021 - Elsevier
genomics and comparative genomics approach for identification and characterization of
potential drug targets in multi-drug resistant … baumannii has emerged as a therapeutic challenge

Genomics for emerging pathogen identification and monitoring: Prospects and obstacles

…, J Farmaha, A Alptekin, H Singh, P Ahluwalia… - …, 2023 - mdpi.com
… In addition, comparative genomics can be limited because genetic changes may have
different … Despite these challenges, comparative genomics has proven to be a valuable tool for …

Isolation and characterization of a bacteriophage and its potential to disrupt multi-drug resistant Pseudomonas aeruginosa biofilms

Y Yuan, K Qu, D Tan, X Li, L Wang, C Cong, Z Xiu… - Microbial …, 2019 - Elsevier
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that can cause serious
problems … Analyses of closely related bacteriophages was carried out by comparing amino …

Rapid Molecular Diagnostics to Inform Empiric Use of Ceftazidime/Avibactam and Ceftolozane/Tazobactam Against Pseudomonas aeruginosa: PRIMERS IV

SR Evans, TTT Tran, AM Hujer, CB Hill… - Clinical Infectious …, 2019 - academic.oup.com
… such as Pseudomonas aeruginosa is a major clinical challenge. Rapid molecular diagnostics
(RMDs) have the potential to inform selection of empiric therapy in patients infected by P. …

Virulence genotyping of drug resistant Pseudomonas aeruginosa clinical isolates in Egypt using multiplex PCR

R Abozahra, MA El-Kholy, K Baraka - Gene Reports, 2021 - Elsevier
aeruginosa are notably challenging because of its high resistance to several classes of
antimicrobial agents; therefore, early diagnosis and control of infections have become vitally …

Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection

…, N Kapel, FHR De Winter, P Jangir… - Nature …, 2021 - nature.com
… One key challenge in this area is to understand how host … genome and all of the other
isolates. C Root-to-tip regression comparing genetic divergence from the reference genome (ie, …

… of blaGES-5 and bla veb-1 genes with multidrug-resistant extend, pandrug resistance patterns (MDR, XDR, PDR), and biofilm formation in Pseudomonas aeruginosa …

FA Ali, SH Bakir, SH Haji, BM Hussen - Cellular and Molecular …, 2021 - cellmolbiol.org
… one of the most challenging targets for antimicrobial therapy … BLAST results comparing the
blaVEB-1 gene from the P. … Prevalence of multi drug resistant Pseudomonas aeruginosa in …

Evaluation of the Xpert Carba-R NxG assay for detection of carbapenemase genes in a global challenge set of Pseudomonas aeruginosa isolates

CM Gill, TE Asempa, IA Tickler… - Journal of clinical …, 2020 - Am Soc Microbiol
… The growing prevalence and diversity of carbapenemase producers among carbapenem-resistant
Pseudomonas aeruginosa (CRPA) isolates warrants an expansion of detection …

Antibiotic resistance, virulence factors and genotyping of Pseudomonas aeruginosa in public hospitals of northeastern Mexico

EM González-Olvera, R Pérez-Morales… - The Journal of Infection …, 2019 - jidc.org
… ); 21 (22.7%) were classified as extremely drug resistant (XDR). Highest resistance rate was
… and the production of β-lactamase is a challenge in the fight against infectious diseases, the …

Imipenem Resistance Mediated by blaOXA-913 Gene in Pseudomonas aeruginosa

DC Moon, AF Mechesso, HY Kang, SJ Kim, JH Choi… - Antibiotics, 2021 - mdpi.com
… by carbapenem-resistant Pseudomonas aeruginosa is becoming a greater challenge. This
study aimed to identify the imipenem resistance mechanism in P. aeruginosa isolated from a …