… 其中,MPTP 诱导的帕金森病小鼠模型是较为广泛使 用的帕金森病动物模型之一 [8-9],可以部分
… Neuroprotective effect of crocin on substantia nigra in MPTP-induced Parkinson’s disease …

… cm) was reduced significantly compared with that of the … to relieve some related symptoms
[8]. The mechanism of action to … Therefore, in this study, MPTP-induced subacute and chronic …

… , which were also assessed with different end points in the MPTP-lesioned marmoset, were
also included in this article, mostly to allow for comparison with clinically efficacious drugs. …

… In this study, we aimed to develop a MPTP-induced chronic … to a rating scale for monkey
PD models through analysis of … PD model, which individually shows symptomatic differences…

… We compared two approved antiparkinson drugs (levodopa … of the relative effects, but also
added rigor by having eight … a priori using a power analysis based on predicted effect size. …

… (PPMRS) immediately prior to MPTP dosing, and 4 and 8 h after dosing. MPTP … with the
Primate Parkinsonism Motor Rating Scale (PPMRS), reaching a significant difference from pre-…

… an analysis of mice behavior using the modified mNSS scale … of the clinical manifestations
of Parkinson’s disease [1, 7, 8]. … this study compared with MPTP-induced parkinsonism and the …

… of 3 subjects with MPTP‐induced parkinsonism revealed no … , and l‐dopa formulations were
all assessed in the MPTP model. … included the comparison of animal rating scales to humans …

… Compared to other toxin models of PD, the MPTP-induced … a semi-quantitative 4-point rating
scale: 0 = no pathology; 1 = … dopaminergic neurons in MPTP-induced Parkinson’s disease …

… neurodegeneration compared to MPTP-induced group and, … the administration of 8 mg/kg
levodopa in MPTP-induced PD mice… assessed in MPTP-induced animals, such as rating scale, …