… Front-Line Treatment of Locally Advanced or Metastatic EGFR-Mutant NSCLC Patients: Efficacy, Acquired Resistance and Perspectives for Subsequent Treatments

MG Denis, J Bennouna - Cancer Management and Research, 2020 - Taylor & Francis
Non-small cell lung cancer (NSCLC) is one of the most … %, with no difference between second
and third-line or more (62… tumors, osimertinib was compared to gefitinib or erlotinib in non-…

Efficacy of vinorelbine monotherapy as third-or further-line therapy in patients with advanced non-small-cell lung cancer

DH Kang, JO Kim, SS Jung, HS Park, C Chung, D Park… - Oncology, 2019 - karger.com
… the survival data for erlotinib treatment beyond second-line therapy [14, … review of efficacy of
erlotinib or gefitinib compared to … of third-line chemotherapy in advanced non-small cell lung

Efficacy and safety of apatinib as third-or further-line therapy for patients with advanced NSCLC: a retrospective study

J Liang, W Gu, J Jin, H Zhang, Z Chen… - Therapeutic …, 2020 - journals.sagepub.com
… has been demonstrated for many cancers, including non-small-cell lung cancer (NSCLC). …
as third-line therapy for patients with advanced NSCLC significantly prolonged PFS compared

[HTML][HTML] A randomized phase 2 study of gefitinib with or without pemetrexed as first-line treatment in nonsquamous NSCLC with EGFR mutation: final overall survival …

JCH Yang, Y Cheng, H Murakami, PC Yang… - Journal of Thoracic …, 2020 - Elsevier
… pemetrexed + gefitinib (P + G) compared with gefitinib monotherapy. … Primary efficacy and
safety results of this study have been … tyrosine kinase inhibitors in nonsmall cell lung cancer

Budget impact of sequential treatment with first-line afatinib versus first-line osimertinib in non-small-cell lung cancer patients with common EGFR mutations

L Westerink, JLJ Nicolai, C Samuelsen… - The European Journal of …, 2020 - Springer
gefitinib and erlotinib with a median PFS of 10.2 months [12]. … the efficacy of third-line
chemotherapy, we assumed similar … osimertinib therapy was compared to EGFR TKIs gefitinib and …

Comparative efficacy of second-and subsequent-line treatments for metastatic NSCLC: a fractional polynomials network meta-analysis of cancer immunotherapies

C Schulz, D Gandara, CG Berardo, R Rosenthal… - Clinical Lung Cancer, 2019 - Elsevier
treatment comparisons within closed loops, namely erlotinib … patients with advanced
non-small-cell lung cancer previously … of erlotinib versus docetaxel as second- or third-line therapy

[HTML][HTML] Third-generation epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small cell lung cancer

NMA Wright, GD Goss - Translational Lung Cancer Research, 2019 - ncbi.nlm.nih.gov
… the efficacy of treatment with third-generation EGFR TKIs. … OS in the second-line and
third-line (or greater) cohorts was … resistance in comparison to erlotinib or gefitinib. Furthermore, …

Cost-effectiveness analysis of the first-line EGFR-TKIs in patients with non-small cell lung cancer harbouring EGFR mutations

MS Holleman, MJ Al, R Zaim, HJM Groen… - The European Journal of …, 2020 - Springer
… conducted to compare the relative efficacy of gefitinib, erlotinib, … NMA of the efficacy of first-line
gefitinib, erlotinib, afatinib, … the second- and third-line treatment strategies after TKI failure […

Efficacy and safety of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) monotherapy for advanced EGFR-mutated non-small cell lung cancer …

HJ Lee, GH Jeong, H Li, MS Kim, JS Kim… - European review for …, 2021 - iris.uniupo.it
… to assess the efficacy and safety of EGFR-TKIs compared to … First-line erlotinib versus
gemcitabine/cisplatin in patients … comparing gefitinib with carboplatin-paclitaxel for chemo-naïve …

First-line tyrosine kinase inhibitors in EGFR mutation-positive non-small-cell lung cancer: a network meta-analysis

MS Holleman, H van Tinteren, HJM Groen… - … and therapy, 2019 - Taylor & Francis
… study compared efficacy and toxicity of first-line treatment … with a significantly better PFS
compared to gefitinib, erlotinib, and … second- or third-line treatment. A previous study showed that …