Remembering the canonical discoverers of the core components of the mammalian cardiac conduction system: Keith and Flack, Aschoff and Tawara, His, and Purkinje

I Cavero, H Holzgrefe - Advances in Physiology Education, 2022 - journals.physiology.org
… Keith emphasized competitive factors. However, … oscillator emitting cyclic SDD events of
variable slopes via the intervention of autonomic transmitters, now denoted as the I f pacemaker

Signatures of the autonomic nervous system and the heart's pacemaker cells in canine electrocardiograms and their applications to humans

AA Rosenberg, I Weiser-Bitoun, GE Billman… - Scientific Reports, 2020 - nature.com
… into how changes in the SAN’s coupled clock system can affect the SAN features present
in the beat intervals, we used a mathematical model consisting of two mechanical oscillators (…

Competition between desired competitive result, tolerable homeostatic disturbance, and psychophysiological interpretation determines pacing strategy

C Foster, JJ De Koning… - … journal of sports …, 2023 - journals.humankinetics.com
… proposing a continuous oscillation between psychological drives (eg, competitive goals) and
historical races for that athlete). Bottom: Progressive depletion of D′ to near zero values in …

A bioelectrical phase transition patterns the first vertebrate heartbeats

BZ Jia, Y Qi, JD Wong-Campos, SG Megason… - Nature, 2023 - nature.com
… In the mature heart, this function is driven by an anatomically localized pacemaker. By …
punctuated by occasional jumps suggests competition among many cellular oscillators, each with …

A dual-clock-driven model of lymphatic muscle cell pacemaking to emulate knock-out of Ano1 or IP3R

EJ Hancock, SD Zawieja, C Macaskill… - Journal of General …, 2023 - rupress.org
… the key mechanisms and system effects that drive pacemaking in LMCs. To achieve this
goal, we have focused on determining the underlying oscillators in a single LMC 10 and how …

Assembly of the cardiac pacemaking complex: electrogenic principles of sinoatrial node morphogenesis

M Easterling, S Rossi, AJ Mazzella… - Journal of Cardiovascular …, 2021 - mdpi.com
… At low levels of coupling, pacemaker cells display independent oscillation. As coupling is
progressively increased: (1) dynamic patterns of entrainment with varying frequency emerge, (2…

The surprising heart revisited: an early history of the funny current with modern lessons

D Noble - Progress in Biophysics and Molecular Biology, 2021 - Elsevier
… rhythm generation in the heart. It did so by turning a theory of pacemaker activity upside down.
pacemaker depolarization to the slow activation of a channel conducting sodium ions into …

Uncertainty analysis of heart dynamics using Random Matrix Theory

A Cheffer, TG Ritto, MA Savi - International Journal of Non-Linear …, 2021 - Elsevier
… Van der Pol oscillators, representing the behavior of the two cardiac pacemakers, SA and
AV … The authors declare that they have no known competing financial interests or personal …

Respiratory–cardiovascular interactions

JP Fisher, T Zera, JFR Paton - Handbook of clinical neurology, 2022 - Elsevier
… and cardiovascular systems contain numerous oscillators, and … the first historic representation
of blood pressure and heart rate … Conflicting results were obtained since the introduction of …

Biological noise is a key determinant of the reproducibility and adaptability of cardiac pacemaking and EC coupling

L Guarina, AN Moghbel… - Journal of General …, 2022 - rupress.org
… A salient feature of healthy cardiac function is the reliable and precise beat-to-beat pacemaking
and amplitude of Ca 2+ transients during EC coupling. In this review, we discuss recent …