[HTML][HTML] Circadian rhythms and the molecular clock in cardiovascular biology and disease

S Crnko, BC Du Pré, JPG Sluijter… - … Reviews Cardiology, 2019 - nature.com
… These components compete for the ROR response element (… emerges during cardiac
differentiation, although oscillation is … produced by the central pacemaker, has produced beneficial …

Remembering the canonical discoverers of the core components of the mammalian cardiac conduction system: Keith and Flack, Aschoff and Tawara, His, and Purkinje

I Cavero, H Holzgrefe - Advances in Physiology Education, 2022 - journals.physiology.org
… Keith emphasized competitive factors. However, … oscillator emitting cyclic SDD events of
variable slopes via the intervention of autonomic transmitters, now denoted as the I f pacemaker

[HTML][HTML] Self-powered cardiovascular electronic devices and systems

Q Zheng, Q Tang, ZL Wang, Z Li - Nature Reviews Cardiology, 2021 - nature.com
… In the past 50 years, the emergence of cardiovascular … by the symbiotic cardiac pacemaker
system and a pacing rhythm is … In 2013, a new type of oscillation generator was designed with …

Circadian pacemaker neurons display cophasic rhythms in basal calcium level and in fast calcium fluctuations

X Liang, TE Holy, PH Taghert - Proceedings of the National …, 2022 - National Acad Sciences
… effects on the PER molecular oscillation. We conclude that … , such as the Sino-Atrial node
of the mammalian heart (45, 46). … Competing interest statement: TEH has a patent on OCPI …

Eliminating contraction during culture maintains global and local Ca2+ dynamics in cultured rabbit pacemaker cells

S Segal, NK Peretz, L Arbel-Ganon, J Liang, L Li… - Cell Calcium, 2019 - Elsevier
… Because the mitochondria are the main source of energy in pacemaker cells (and other heart
tissues [32]), … From two competing oscillators to one coupled-clock pacemaker cell system …

[PDF][PDF] TRPM4 mediates a subthreshold membrane potential oscillation in respiratory chemoreceptor neurons that drives pacemaker firing and breathing

K Li, SBG Abbott, Y Shi, P Eggan, EC Gonye… - Cell reports, 2021 - cell.com
… phase and past the peak of the oscillation waveform to reach its maximal amplitude during
the repolarizing phase before falling again to a nadir at the most hyperpolarized oscillation-…

Frequency-Dependent Properties of the Hyperpolarization-Activated Cation Current, If, in Adult Mouse Heart Primary Pacemaker Myocytes

W Hu, RB Clark, WR Giles, C Kondo… - International Journal of …, 2022 - mdpi.com
… roles of I f in the generation of pacemaker activity in the mouse SAN were published [39,40].
Details of these findings will be presented and put into the context of our results in Section 4. …

[HTML][HTML] Drivers of sinoatrial node automaticity in zebrafish: comparison with mechanisms of mammalian pacemaker function

MR Stoyek, EA MacDonald, M Mantifel… - Frontiers in …, 2022 - frontiersin.org
… known principal components of the coupled membrane-Ca 2+ oscillator pacemaker system
in mammals were applied to the heart via the addition of stock solutions at the edge of the …

Competition between desired competitive result, tolerable homeostatic disturbance, and psychophysiological interpretation determines pacing strategy

C Foster, JJ De Koning… - … journal of sports …, 2023 - journals.humankinetics.com
… proposing a continuous oscillation between psychological drives (eg, competitive goals) and
historical races for that athlete). Bottom: Progressive depletion of D′ to near zero values in …

Application of Spectral Methods of Analysis for Description of Ultradian Biorhythms at the Levels of Physiological Systems, Cells and Molecules

ME Astashev, DA Serov, SV Gudkov - Mathematics, 2023 - mdpi.com
… Over the past 60 years, scientists around the world have … the literature on the functioning of
circadian pacemakers, so we will not … We suggest that metabolic oscillators may be universal …