… Whereas there is substantial evidence that modulation of T cell co-stimulation affects … by
co-stimulatory signals. We hypothesized that negative co-stimulation limits T cell differentiation, …

… expressed T-cell receptors (TCRs). To address this issue, we used a high-throughput
approach to profile the αβ TCR repertoires of human naive and effector/memory CD4 + T-cell …

… strength of the antigen and costimulatory signals, so that stronger … in specific polyfunctional
subpopulations, we visualized … T cell response, mechanistically linking alloantibody to T cell…

… analysis, we found that this subpopulation is similar to virus-… complement of co-stimulatory,
co-inhibitory, and signaling adhesion molecules that are known to tune the threshold of T cell …

… was used to generate full length complementary DNA (cDNA) … of synergism between
costimulatory and ICB components of … CD8 + T cell clusters corresponded to Prog1 (clusters 10 …

… ) isotype that does not fix complement. A mutation in the … -human IgG4 (SouthernBiotech)
to determine the percentage of cells with bound trispecific Ab on the indicated subpopulations …

… Unsupervised clustering differentiated patients based on … the CD3 + CD4 − T-cell
subpopulation]) and permeabilized with … -matched control subjects as a complement to our recent …

… differentiated cells, lose the expression of costimulatory … functional complexity of the different
subpopulations of these memory-… exhausted T cell features, such as complementary surface …

… participate in T cell activation, act as costimulatory and signaling … of cells expressing
complement regulation protein (CD55) … cells are terminally differentiated subpopulations of Tregs …

… We assessed single cell gene expression and T cell receptor … V-gene, complementarity
determining region 3 (CDR3) … of CB Tregs expressing the costimulatory molecule CD226 (Figure …