… This article describes the works done on enzyme models and the computational … of Kirby’s
enzyme models were used to design simvastatin prodrugs (Figure 7) by linking the statin-free …

… statins, or substitute for patients who are intolerant to statins, … In the era of advanced
technology, various computational … on proton transfers in Kirby’s enzyme model by linking the free …

… were investigating the effects of statins in combination or as … gained without the use of
computational data. However, to … Bruice’s cyclization of dicarboxylic semiesters and Kirby’s acid-…

… enzyme models were utilized in my prodrug design approach which was accomplished using
computational calculations based … [73, 79, 80] and statins for treatment of high cholesterol …

… and kinetic studies described in this paper is based on intramolecular process using molecular
… Computationally designed prodrugs of statins based on Kirby’s enzyme model. Journal of …

… Analyzing the efficiency of proton transfer to carbon in Kirby’s enzyme model: A computational
… Computationally designed prodrugs of statins based on Kirby's enzyme model. J Mol …

… However, the model continued to under-predict the statin … is SN-38, the active anti-cancer
metabolite of the prodrug … in transporters and metabolizing enzymes is a significant limitation …

… intervention were limited to proteins like enzymes, G-protein coupled … statin-treated participants
following a single oral dose of MK-0616 (-001) or of plasma LDL-C from baseline in statin-…

… potent in enzymatic PA N assays, showcasing the model’s … issue, probably through prodrug
formulations—following the … proven by enzymatic experiments and computational theoretical …

… developed [30,31,32] to investigate bile recirculation and AMLO DDI prediction with other
drugs. Therefore, we first developed a model … to implement these metabolizing enzymes, total …