… for αCT1 in increasing skin wound closure rate, tempering … Based on the effect of αCT1
on in vitro cell migration tracks in … environment that occurs in a human skin wound and in the …

… Two predominant CX in human epidermis CX43 (encoded by … cell migration studies previously
performed in keratinocytes … levels of CX26 and hemichannel activity within keratinocytes …

… comparisons in cell migration rate (HaCaT migration assay) … connexins play critical roles
in cell migration in a variety of … did not significantly enhance the keratinocyte migration in the …

… environment that occurs in a human skin wound and in the … the peptide also increases
keratinocyte motility rate –thereby … Based on the effect of αCT1 on in vitro cell migration tracks in …

… migration and wound closure in fibroblasts, keratinocytes, … regulates the connexin to GJ
transition, by slowing the rate at which … Further, αCT1 treatment has been shown to increase GJ …

… available peptides are optimized, and new peptide mimetics … -over rate of Cx proteins,
through which peptides can bind to … , as it can potentially boost the effects of peptides due to an …

… The epidermis is composed by four layers of keratinocytes at … CX43 is the most abundant
connexin in the human skin; … differentiation, and higher cell migration than CX26WT-models, …

… They were implicated in enhanced cell migration, … on human epidermal keratinocytes and
dermal fibroblasts in vitro. Blocking GJIC using these peptides increased cell migration rates, …

… evident in HaCaT cells, a model human keratinocyte cell line (… of the normal human epidermis
also induced an increase in … The presence of enhanced levels of ATP released from cells …

… This interaction leads to increase in Ca 2+ levels mediated … siRNA or Cx peptide mimetics
(small peptides which inhibit … Like epidermal wound healing, here also cell migration and …