… Finally, we outline the remaining hurdles for T cell-based HIV prevention and … efficacy trials,
and the anticipated introduction of long-acting injectable ART may further complicate future …

… in 2010, followed by an efficacy trial of oral PrEP using TDF/… an efficacious, female-controlled
HIV prevention choice. The … events, and this observation has held for women as well as …

… phase 2b efficacy trials was designed around the beginning of this millennium before the
HIV-1 … with results emerging in not too distant future. The most promising antibodies and T -cell …

… clinical trials until adequate validation of these assays is completed. With regard to the future
use … infectious virions and are inadequate for determining the effectiveness of interventions …

… trials. In vivo delivery of gene-editing tools to either target the virus, boost immunity or protect
cells from infection, also holds promise for future HIV … efficacy of therapies that target the HIV…

… The ongoing REPRIEVE trial is assessing the efficacy of a statin … rate in the control group as
low as 8.4 events/1,000 PY. … for future trials. In addition, other strategies may be useful for the …

… The efficacy of individual approaches is currently far below … subsequent daughter cells
refractory to future infection), this may … HIV vaccine trial showed only approximately 30% efficacy …

… has been incorporated into 159 clinical studies since 2000 and is increasingly being included
in trials to assess the efficacy … This research will assist the design of future trials involving …

… risk of onward HIV transmission. Findings will inform future RCTs testing the effectiveness
of integrative, behavioural interventions to optimize HIV/AIDS treatment and prevention …

… effectiveness. Section V concludes by highlighting the broader implications of our findings for
policies and future … attrition across treatment and control groups by these characteristics (at …