Accumulation of copy number alterations and clinical progression across advanced prostate cancer
E Grist, S Friedrich, C Brawley, L Mendes, M Parry… - Genome Medicine, 2022 - Springer
… recurrence and death from prostate cancer [4, 5, 10]. … burden of copy number alteration is
non-linearly associated with risk of clinical progression and death in advanced prostate cancer, …
non-linearly associated with risk of clinical progression and death in advanced prostate cancer, …
A DNA copy number alteration classifier as a prognostic tool for prostate cancer patients
W Ebrahimizadeh, KP Guérard, S Rouzbeh… - … Journal of Cancer, 2023 - nature.com
… with low or intermediate risk of relapse. Several somatic DNA … hazard modelling to predict
biochemical recurrence. … Combinations of specific CNAs, as well as global CNA burden (…
biochemical recurrence. … Combinations of specific CNAs, as well as global CNA burden (…
[HTML][HTML] Exome sequencing identified six copy number variations as a prediction model for recurrence of primary prostate cancers with distinctive prognosis
J Liu, J Yan, R Mao, G Ren, X Liu, Y Zhang… - Translational Cancer …, 2020 - ncbi.nlm.nih.gov
… based model can correctly predict 73% of relapsed cases and 75% … recurrent regions of
genomic loss and gain, and confirmed that the burden of SCNAs (somatic copy number alteration…
genomic loss and gain, and confirmed that the burden of SCNAs (somatic copy number alteration…
Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer
J Fernandez-Mateos, GD Cresswell, N Trahearn… - Nature Cancer, 2024 - nature.com
… We found a significantly increased burden of CNAs at relapse, with high PGA levels (Fig.
3e)… We then used the copy number profiles to add the recurrent sample to the phylogenetic …
3e)… We then used the copy number profiles to add the recurrent sample to the phylogenetic …
Copy number alterations are associated with metastatic-lethal progression in prostate cancer
X Wang, CS Grasso, KM Jordahl, S Kolb… - … cancer and prostatic …, 2020 - nature.com
… We detected 15 recurrent CNAs were associated with … c ROC curves for predicting
metastatic-lethal prostate cancer … d ROC curves for predicting metastatic-lethal prostate cancer …
metastatic-lethal prostate cancer … d ROC curves for predicting metastatic-lethal prostate cancer …
Genomic alteration burden in advanced prostate cancer and therapeutic implications
… how a tumor's mutation burden may help predict response to … However, copy number
alterations (CNA) of individual genes … with respect to biochemical relapse following definitive …
alterations (CNA) of individual genes … with respect to biochemical relapse following definitive …
Exploration of the tumor mutational burden as a prognostic biomarker and related hub gene identification in prostate cancer
L Wang, Y Yao, C Xu, X Wang… - Technology in cancer …, 2021 - journals.sagepub.com
… survival time and lower cancer recurrence, while elevated … In this study, we used DEGs
expression to predict the content … relationship between somatic copy number variation (CNV) …
expression to predict the content … relationship between somatic copy number variation (CNV) …
Deep learning-based multi-omics integration robustly predicts relapse in prostate cancer
Z Wei, D Han, C Zhang, S Wang, J Liu, F Chao… - Frontiers in …, 2022 - frontiersin.org
… Bioinformatics analyses of two relapse-associated … , copy number analysis and immune cell
infiltration analysis. … was observed between the burden of CNVs and PCa relapse and death (…
infiltration analysis. … was observed between the burden of CNVs and PCa relapse and death (…
… -scale transition number in circulating tumor cells identifies a chromosomal instability biomarker associated with poor outcome in castration-resistant prostate cancer
JD Schonhoft, JL Zhao, A Jendrisak, EA Carbone… - Cancer research, 2020 - AACR
… -number alteration predicts for an inferior survival and clinical outcomes across a range of …
Furthermore, data on the single-cell nature of copy number or LST burden in single tumor cells …
Furthermore, data on the single-cell nature of copy number or LST burden in single tumor cells …
Genome-wide association study of germline copy number variations reveals an association with prostate cancer aggressiveness
S Brezina, M Feigl, T Gumpenberger… - …, 2020 - academic.oup.com
… copy number alterations are commonly present in cancer … novel biomarkers to predict prostate
cancer aggressiveness at … is associated with biochemical recurrence and metastasis. In a …
cancer aggressiveness at … is associated with biochemical recurrence and metastasis. In a …