Coronavirus disease 2019 (COVID‐19): do angiotensin‐converting enzyme inhibitors/angiotensin receptor blockers have a biphasic effect?

R Sommerstein, MM Kochen, FH Messerli… - Journal of the …, 2020 - Am Heart Assoc
R Sommerstein, MM Kochen, FH Messerli, C Gräni
Journal of the American Heart Association, 2020Am Heart Assoc
China, in December 2019. 1 As of March 20, 2020, 244 602 patients have tested positive
worldwide; and 10 031 (4.1%) of these patients were reported to be deceased because of
COVID-19. 2 According to the Chinese Center for Disease Control and Prevention, as of
February 11, 2020 with 44 672 confirmed patients, several comorbidities, including
cardiovascular diseases and diabetes mellitus, seem to be involved in COVID-19 patients
with a severe course. 3 In this largest analysis, 10.5% of fatal cases occurred in patients with …
China, in December 2019. 1 As of March 20, 2020, 244 602 patients have tested positive worldwide; and 10 031 (4.1%) of these patients were reported to be deceased because of COVID-19. 2 According to the Chinese Center for Disease Control and Prevention, as of February 11, 2020 with 44 672 confirmed patients, several comorbidities, including cardiovascular diseases and diabetes mellitus, seem to be involved in COVID-19 patients with a severe course. 3 In this largest analysis, 10.5% of fatal cases occurred in patients with cardiovascular disease and 6% in patients with arterial hypertension. 3 It is unclear whether these comorbidities contribute to the higher risk.
Am Heart Assoc
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