Engineered skeletal muscles for disease modeling and drug discovery

J Wang, A Khodabukus, L Rao, K Vandusen… - Biomaterials, 2019 - Elsevier
… disease to accurately predict drug efficacy and toxicity in humans has prompted the development
in vitro models of human skeletal muscle that fatefully recapitulate cell and tissue level …

Predictors for fibrosis regression in chronic HCV patients after the treatment with DAAS: results of a real-world cohort study

H Soliman, D Ziada, M Salama… - … Metabolic & Immune …, 2020 - ingentaconnect.com
… or more) evident by transient elastography (TE) examination … To analyze the relationship
between pretreatment possible … cytokines such as transforming growth factor 1 β, hyaluronic acid…

Perlecan in pericellular mechanosensory cell-matrix communication, extracellular matrix stabilisation and mechanoregulation of load-bearing connective tissues

F Guilak, AJ Hayes, J Melrose - International journal of molecular …, 2021 - mdpi.com
… to changes in osmolarity with transient changes in intracellular Ca 2… proteins and growth
factors, eg, transforming growth factor-β (TGF-β… Correlation of the type VI collagen and perlecan …

[HTML][HTML] Mechanical feed-forward loops contribute to idiopathic pulmonary fibrosis

MAT Freeberg, A Perelas, JK Rebman… - The American Journal of …, 2021 - Elsevier
… , Piezo channels, transient receptor potential channels, and … forces within tissues activate
latent transforming growth factor-β (… Tissue stiffness, measured in kilopascals (kPa), measures

Liver stiffness, hepatorenal index, and microRNA-130b as predictors for chronic kidney disease in patients with non-alcoholic fatty liver disease

MYE Hassafy, AS Elhadidi, MM Tahoon… - Egyptian Liver …, 2023 - Springer
… A comparison between proportions was determined by the chi-… In the current study, a positive
correlation was found … fat accumulation through insulin-like growth factor binding protein 2 (…

Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

M Parola, M Pinzani - Molecular aspects of medicine, 2019 - Elsevier
Hepatic macrophages, essential to maintain tissue homeostasis and ensure rapid responses
to hepatic injury, include Kupffer cells (KC, liver … accumulate in the injured liver. These cells, …

Prevalence and Crucial Parameters in Diabesity-Related Liver Fibrosis: A Preliminary Study

S Suwała, A Białczyk, K Koperska, A Rajewska… - Journal of Clinical …, 2023 - mdpi.com
… by an objective and validated method of transient … diabesity, the correlation between liver
stiffness index and GGTP … -fused long-acting fibroblast growth factor 21 (FGF21) analogue as a …

The role of fibrosis and liver-associated fibroblasts in the pathogenesis of hepatocellular carcinoma

J Baglieri, DA Brenner, T Kisseleva - International journal of molecular …, 2019 - mdpi.com
… fibrosis, positively correlate with HCC risk [23,24,25]. … by several cytokines and growth factors,
which are secreted by … -shaped cells of the connective tissues that produce collagen. Later …

NAFLD is associated with quiescent rather than active Crohn's disease

S McHenry, M Glover, A Ahmed, Q Alayo… - Inflammatory bowel …, 2024 - academic.oup.com
Transient elastography and liver biopsy were requested by … transforming growth factor β
concentration measured enzyme-… the absence of correlation between severity of liver fat (PDFF) …

Hexokinase 2 couples glycolysis with the profibrotic actions of TGF-β

X Yin, M Choudhury, JH Kang, KJ Schaefbauer… - Science …, 2019 - science.org
… muscle actin, and connective tissue growth factor) and stabilized … Therefore, we further
assessed the relationship between … (A) AKR-2B cells were transiently transfected with a YAP/TAZ …