Current understanding of the role of neuronal calcium sensor 1 in neurological disorders

J Bandura, ZP Feng - Molecular Neurobiology, 2019 - Springer
… with neuronal growth cones in the developing spinal cord. … plasticity independent of its
modulation of calcium channels. … , NCS-1 overexpression in primary cultured cortical neurons was …

Mice lacking neuronal calcium sensor-1 show social and cognitive deficits

E Ng, J Georgiou, A Avila, K Trought, HS Mun… - Behavioural Brain …, 2020 - Elsevier
… branching and spine density in cortical neurons of Ncs1 -/- … Finally, we anticipated abnormal
long-term synaptic plasticityoverexpression of NCS-1 in cultured rat cortical neurons [73] …

[HTML][HTML] Neuronal calcium sensor 1 (NCS1) dependent modulation of neuronal morphology and development

TT Fischer, LD Nguyen, BE Ehrlich - FASEB journal: official …, 2021 - ncbi.nlm.nih.gov
… a reduction in dendritic complexity and spine density in the prefrontal cortex and the dorsal
… In contrast, overexpression of NCS1 in the dentate gyrus enhances synaptic plasticity and …

Calcium sensors in neuronal function and dysfunction

RD Burgoyne, N Helassa… - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
plasticity, long-term potentiation (LTP) and long-term depression (LTD). Interestingly, the …
the function of NCS-1 derives from overexpression or knockout studies. Overexpression in …

[HTML][HTML] Neuronal Calcium Sensor-1 Protects Cortical Neurons from Hyperexcitation and Ca2+ Overload during Ischemia by Protecting the Population of GABAergic …

EG Varlamova, EY Plotnikov, EA Turovsky - International Journal of …, 2022 - mdpi.com
… NCS-1 is known to regulates many aspects of neuronal plasticity, such as short-term plasticity
[… Neuronal studies have shown that the overexpression of NCS1 induces neurite sprouting …

Neuronal Calcium Sensor-1: A Zinc/Redox-Dependent Protein of Nervous System Signaling Pathways

VE Baksheeva, AA Zamyatnin Jr, EY Zernii - Molecular Biology, 2023 - Springer
… in animals genetically modified to overexpress the new protein. … In humans, the NCS-1
content in cortical neurons is several … in dendrites of spinal ganglion neurons and bodies and …

[HTML][HTML] Contribution of neuronal calcium sensor 1 (Ncs-1) to anxiolytic-like and social behavior mediated by valproate and Gsk3 inhibition

LAV Magno, H Tenza-Ferrer, M Collodetti… - Scientific Reports, 2020 - nature.com
… Ncs-1 overexpression in mouse frontal cortex caused responses similar to … induce Ncs-1
protein expression by increasing its translation through recruitment of Fxr1. We overexpressed

[HTML][HTML] Calcium-Associated Proteins in Neuroregeneration

M Lisek, J Tomczak, T Boczek, L Zylinska - Biomolecules, 2024 - mdpi.com
… kinase activity impairs structural and functional plasticity [18]. … Neuronal calcium sensor-1
(NCS-1) is a member of the NCS … The overexpression of NCS-1 induces neurite sprouting and …

Synaptogenic gene therapy with FGF22 improves circuit plasticity and functional recovery following spinal cord injury

A Aljović, A Jacobi, M Marcantoni, F Kagerer… - EMBO Molecular …, 2023 - embopress.org
… Interestingly, we demonstrate that overexpression of FGF22 induced a significant increase
in contact … In the hindlimb motor cortex silencing experiment, we overexpressed FGF22 in …

Endoplasmic reticulum in metaplasticity: from information processing to synaptic proteostasis

S Khan - Molecular Neurobiology, 2022 - Springer
plasticity of plasticity (metaplasticity) within the neuron to … For example, misfolded Sec61/Sec62
is overexpressed upon … AIS in the cortical pyramidal neurons carries ER to form a spine