… , etc.) that have to be integrated into lineage-specific transcriptional programs leading to the
… , resulting in the deacetylation of histones and a closed chromatin structure. HDACs might …

… with increased deacetylated histone 3 (H3) occupancy at Nuc-1. This repressive chromatin
… mixture of multiply infected cells with various HIV integration sites, were used as our model …

… , integration site, and the surrounding chromatin environment. … Histone acetylation is
catalyzed by a group of enzymes … tighter chromatin environment and a loss of RNAPII occupancy …

… following histone deacetylase (… Histone deacetylase inhibitors are widely studied HIV
latency-reversing agents (LRAs). VOR, an HDACi, induces histone acetylation and chromatin …

… integration status of the viral DNA: pre- and post-integration … by increasing deacetylated
histone 3 occupancy at Nuc-1 [91]… while the activating chromatin remodeling complex PBAF was …

… chromatin decondensation and gene expression. In oncology clinical trials, histone acetylation
… In this study, we used a Jurkat 2D10 cell line that contains a single integrated HIV provirus…

… of HIV-1 DNA and before its integration in the host chromatin [43]. In … role in coordinating
nucleosome occupancy, possibly through … For instance, acetylation of lysine residues by histone …

… recruitment [26], whereas acetylation on the lysine 50 residue … process, Tat deacetylation by
the histone deacetylase (HDAC… role of the chromatin state at the site of proviral integration as …

… demonstrate the importance of acetylation-related events … with the repressive SWI/SNF
chromatin remodeling machinery (46)… likely also resemble different areas of integration, as well as …

… Counterregulation of chromatin deacetylation and histone deacetylase occupancy at the
integrated promoter of human immunodeficiency virus type 1 (HIV-1) by the HIV-1 repressor …