CpG oligonucleotides as vaccine adjuvants

N Kayraklioglu, B Horuluoglu, DM Klinman - DNA Vaccines: Methods and …, 2021 - Springer
CpG ODN were effective as vaccine adjuvants in multiple species. CpG ODN adjuvanted
AVA induced a rapid and protective toxin-neutralizing Ab response in guinea pigs [113]. Calves …

Vaccine adjuvants: Understanding the structure and mechanism of adjuvanticity

S Shi, H Zhu, X Xia, Z Liang, X Ma, B Sun - Vaccine, 2019 - Elsevier
vaccine adjuvants, including optimization of adjuvant formulations, design of new adjuvants
and … As efficient vaccine adjuvants, CpG ODN can promote the immunostimulatory effect of …

Evaluation of immunogenicity and protective efficacy of a CpG-adjuvanted DNA vaccine against Tembusu virus

H Chen, M Yan, Y Tang, Y Diao - Veterinary Immunology and …, 2019 - Elsevier
… a DNA vaccine based on a recombinant pre-membrane (prM) and envelope (E) protein,
using CpG oligodeoxynucleotide (ODN) as an adjuvanted, … , a DNA vaccine pVAX1-prM/E-CpG, …

The content of CpG-DNA in antigen-CpG conjugate vaccines determines their cross-presentation activity

RM Clauson, B Berg, B Chertok - Bioconjugate Chemistry, 2019 - ACS Publications
… one CpG per OVA. Our findings suggest that tuning molecular composition of antigen-CpG
molecular tuning and may be useful for continued development of antigen-CpG vaccines. …

The CpG molecular structure controls the mineralization of calcium phosphate nanoparticles and their immunostimulation efficacy as vaccine adjuvants

R Khalifehzadeh, H Arami - Nanoscale, 2020 - pubs.rsc.org
… While this study is focused to evaluate CaP-CpG nanoparticles as potential adjuvants for
enhanced vaccine delivery applications, we envision that our results will also enable better …

[HTML][HTML] An overview of vaccine adjuvants: current evidence and future perspectives

A Facciolà, G Visalli, A Laganà, A Di Pietro - Vaccines, 2022 - mdpi.com
… It has been shown in a murine model that CpG-B ODN as an adjuvant causes
considerable and long-lasting antibody production, better than alum-adjuvated or non-adjuvated …

CpG-adjuvanted hepatitis B vaccine (HEPLISAV-B®) update

GH Lee, SG Lim - Expert Review of Vaccines, 2021 - Taylor & Francis
… Expert opinion: HEPLISAV-B, a CpG adjuvant mixed with HBsAg, is more efficacious and
produced earlier seroprotection compared to existing vaccines, with a favorable safety profile. …

A CpG-riched plasmid as vaccine adjuvant reduce antigen dose of an inactivated Vibrio anguillarum vaccine in turbot (Scophthalmus maximus L.)

X Sun, P Jin, Q Liu, Q Wang, Y Zhang, X Liu - Fish & shellfish immunology, 2020 - Elsevier
CpG reduce antigen dose in mice [16] and high dosage may increase product-cost and
workload, we wonder whether CpG ODNs could be used as a safer adjuvant … class B CpG ODNs …

A DNA nanodevice-based vaccine for cancer immunotherapy

S Liu, Q Jiang, X Zhao, R Zhao, Y Wang, Y Wang… - Nature Materials, 2021 - nature.com
DNA nanodevice vaccine generated by precisely assembling two types of molecular adjuvants
CpG motifs (TLR9 agonist) as adjuvant 2 (Supplementary Fig. 4). The sticky ends of the …

CpG-based nanovaccines for cancer immunotherapy

W Chen, M Jiang, W Yu, Z Xu, X Liu, Q Jia… - International Journal …, 2021 - Taylor & Francis
… On the basis of this technical theory, studies have proposed an innovative research idea,
using CpG DNA not only as the immune adjuvant, but also as the carrier material of …