20(S)-Protopanaxadiol Exerts Antidepressive Effects in Chronic Corticosterone-Induced Rodent Animal Models as an Activator of Brain-Type Creatine Kinase

Z Zhu, Y Cheng, X Han, T Wang, H Zhang… - Journal of Agricultural …, 2024 - ACS Publications
creatine supplementation could significantly antagonize the depression-like behavior and
hippocampal cell proliferation … The position of the bottles was swapped after 12 h to prevent

The possible beneficial effects of creatine for the management of depression

FL Pazini, MP Cunha, ALS Rodrigues - Progress in Neuro …, 2019 - Elsevier
… a single administration of creatine shares with ketamine the ability to reverse
corticosterone-induced depressive-like … Of note, the acute administration of creatine was able to …

Protective effects of agmatine against corticosterone-induced impairment on hippocampal mTOR signaling and cell death

G Olescowicz, TB Sampaio… - Neurotoxicity …, 2020 - Springer
… , including a reduction in hippocampal cell proliferation and neuronal … can prevent the
increase in corticosterone-induced cell death in vitro using an immortalized mouse hippocampal

Creatine in neuroprotection and neurotoxicity

S Kanekar - Natural Molecules in Neuroprotection and …, 2024 - Elsevier
… In cultured hippocampal brain slices, creatine treatment improved response to hypoxia/ischemia
and … Creatine prevents ROS production in hyperglycemia, by activating mitochondrial …

Role of adult hippocampal neurogenesis in the antidepressant actions of lactate

A Carrard, F Cassé, C Carron, S Burlet-Godinot… - Molecular …, 2021 - nature.com
… of agomelatine, creatine, or fluoxetine does not affect hippocampal progenitor … that reversal
of corticosterone-induced impairment of hippocampal progenitor proliferation contributes to …

Effects of creatine supplementation on brain function and health

SC Forbes, DM Cordingley, SM Cornish, B Gualano… - Nutrients, 2022 - mdpi.com
… supplementation could be potentially neuroprotective by preventing losses of dopaminergic
… Similarly for PTSD, two studies have described reduced creatine levels in the hippocampal

mTORC1-dependent signaling pathway underlies the rapid effect of creatine and ketamine in the novelty-suppressed feeding test

FL Pazini, JM Rosa, A Camargo, DB Fraga… - Chemico-Biological …, 2020 - Elsevier
… the ability to reverse corticosterone-induced depressive-like … , and coordinately modulates
cell proliferation and survival by … caused by creatine, besides preventing the ketamine-…

Ketamine, but not fluoxetine, rapidly rescues corticosterone-induced impairments on glucocorticoid receptor and dendritic branching in the hippocampus of mice

DB Fraga, A Camargo, G Olescowicz, DA Padilha… - Metabolic brain …, 2021 - Springer
… patients have decreased levels of GR mRNA in the hippocampus (Modell et al. 1997). The
reduction in GR immunocontent in the hippocampus of CORT-exposed mice observed in the …

Creatine in health and disease

RB Kreider, JR Stout - Nutrients, 2021 - mdpi.com
Creatine supplementation has also been reported to prevent … 10 mg/kg, po) abolished
corticosterone-induced depressive-like … a greater effect on hippocampal neurogenesis via the Wnt/…

Lutein prevents corticosterone-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities

ALB Zeni, A Camargo, AP Dalmagro - Pharmacology Biochemistry and …, 2019 - Elsevier
reducing oxidative stress in the mice's hippocampus, prefrontal cortex, and plasma, as well
as protecting hippocampus … , CORT reduced cell proliferation and neuronal differentiation, as …