… that Gab2 is essential for Bcr-Abl-mediated transformation of … These data hint at a more
general phenomenon of Gab2 … Gab2 has a similar role for FLT3-mediated transformation. Thus…

… Moreover, we highlight their key role in the self-renewal and … -ABL1-mediated transformation,
as GAB2 mutation in SH2 … By exploring the function of PTEN in BCR-ABL–expressing Ba…

… GRB2 is direct interactor of BCR–ABL, and highlight the critical role of Y177 in mediating …
multiple components within the BCR–ABL complex, namely SHC1, cCBL, GAB2 and CRKL […

… For example, Gab2 is an essential effector of Bcr-Abl in chronic … Moreover, Gab2 is required
for transformation of primary murine … Our in vivo data highlighting a critical role of Gab2 in this …

… This demonstrates that Y177 is not crucial for lymphocyte transformation by BCR-ABL; its
absence changes the leukemia phenotype and extends disease latency. Our data demonstrate …

… Finally, we examined whether granular localization is involved in the transformation activity
of BCR-ABL. To this end, the lymphoid cell line Ba/F3 was utilized. Proliferation of this cell …

… , including RAS/RAF/MAPK, PI3K/AKT/mTOR, JAK/STAT, and WNT/β-catenin, briefly
presented below, responsible for the different aspects of BCR-ABL-1-induced transformation. …

… Here, we aimed to explore the role of GAB2 in pan-cancer. … ) found that BCR-ABL protein
contained tyrosine autophosphorylation of residue Y177 can recruit GRB2-GAB2 complex, then …

… transformation in cancer. Different cell lines and murine models show that BCR-ABL … refers
to pBCR) in complex with GRB2 plays a key role in activation of Ras, other pathways, such as …

… transformation and our recent data from Gab2 −/− mice provided the rationale for further
analysis of MCs in CML. Therefore, we aimed to analyze the role … discover a crucial role of MCs …