Evaluation of sucrose laurate as an intestinal permeation enhancer for macromolecules: ex vivo and in vivo studies

F McCartney, M Rosa, DJ Brayden - Pharmaceutics, 2019 - mdpi.com
… , isolated rat intestinal tissue mucosae, and rat intestinal … increases in paracellular marker
fluxes and TEER reductions with 5 … [62] also compared C 10 with sucrose caprate in promoting

[HTML][HTML] Sodium glycodeoxycholate and sodium deoxycholate as epithelial permeation enhancers: in vitro and ex vivo intestinal and buccal bioassays

DJ Brayden, V Stuettgen - European Journal of Pharmaceutical Sciences, 2021 - Elsevier
… the P app of the paracellular marker, FITC-dextran 4000 (FD4… H]-octreotide flux across isolated
rat colonic mucosae (iv) the … were efficacious at promoting transepithelial peptide flux, but …

Exposure to a nonionic surfactant induces a response akin to heat-shock apoptosis in intestinal epithelial cells: implications for excipients safety

RJ Cavanagh, PA Smith, S Stolnik - Molecular Pharmaceutics, 2019 - ACS Publications
permeability as indicated by the release of LDH, internalization of FD4, and as a marker of
nuclear membrane permeability… components will likely promote immunogenic response in the …

A Narrative Review on Non-Invasive Drug Delivery of Teriparatide: A Ray of Hope

N Mittal, G Sharma, OP Katare… - Critical Reviews™ in …, 2023 - dl.begellhouse.com
… of glycoprotein present in mucus enhances the mucoadhesive properties of thiolated chitosan.…
CriticalSorbpromotes permeation of flux markers across isolated rat intestinal mucosae

Nasal administration and plasma pharmacokinetics of parathyroid hormone peptide PTH 1-34 for the treatment of osteoporosis

RG Pearson, T Masud, E Blackshaw, A Naylor… - Pharmaceutics, 2019 - mdpi.com
… benefit from a permeation enhancer to promote absorption across the nasal mucosa into the
… liquid nasal spray formulation containing the permeation enhancer polyethylene glycol (15)-…

Development and in vivo evaluation of intranasal formulations of parathyroid hormone (1-34)

D Wang, Y Du, W Zhang, X Han, H Zhang, Z Wang… - Drug …, 2021 - Taylor & Francis
permeation enhancer to effectively and safely promote the absorption of PTH(1-34) across
the nasal mucosa. … macromolecular drugs crossing the nasal and intestinal mucosa in phase I …

Enhanced permeation by amphiphilic surfactant is spatially heterogenous at membrane and cell level

R Cavanagh, S Shubber, D Vllasaliu… - Journal of Controlled …, 2022 - Elsevier
… in permeability enhancement technologies to achieve mucosal … of pulmonary or diseases of
intestinal tract. Efficient … that Kolliphor® HS15 promotes permeability across epithelial layers […

Recent development of polymer nanomicelles in the treatment of eye diseases

R Cai, L Zhang, H Chi - Frontiers in bioengineering and …, 2023 - frontiersin.org
… time on the eye surface and promote corneal permeability. While the hydrophilic corneal …
attributes, augmented mucosal adhesiveness, elevated corneal permeation, and demonstrated …

Recombinant expressing angiopep-2 fused anti-VEGF single chain Fab (scFab) could cross blood–brain barrier and target glioma

X Ji, H Wang, Y Chen, J Zhou, Y Liu - AMB Express, 2019 - Springer
… However, the poor permeability of the macromolecules across the blood–brain barrier,
determined by multifactorial anatomical and physiological milieu, restricts the clinical therapeutic …