… expressing pleiotropic phenotypic and genetic changes. Given … the adaption affected virulence
traits for animal hosts. Our … , 39, 83) in that they did not increase in virulence. Instead, we …

… cryptococcal cells to grow, disseminate, and invade the host … host interaction but is
unlikely to be significant in virulence [50… progenies; the bases of genetic variability, pathogen …

… virulence; however, our current understanding of how passage through a mammalian host
alters Cryptococcus neoformans … cryptococcal genome is highly malleable such that genetic …

… host to cause deadly infection will guide our development of … studies show the genetic
capacity for inositol utilization by C. … Since we observed that inositol can induce capsule growth, …

… and increased antifungal and macrophage susceptibility [35]. In addition, Δpck1 mutants …
Cryptococcus neoformans virulence is enhanced after growth in the genetically malleable host …

… of the replication of Cryptococcus neoformans in … increase in virulence [57]. This work also
illustrated how the phenomenon of increased microbial virulence in setting of impaired hosts …

… fungal pathogens Cryptococcus neoformans and Cryptococcus … in macrophages or to kill
animal hosts. Our findings suggest … understanding of the genetic architecture of virulence traits, …

… virulence phenotypes arising from passage across hosts and … cryptococcal genome is highly
malleable such that genetic … were perhaps more virulent because of genetic changes that …

… host requires genetic diversity within a microbial population. … and Cryptococcus neoformans
resulted in an increase in the … , a virulence factor which protects the bacterium from the host …

… of virulence determinants of human pathogenic fungi such as Cryptococcus neoformans or
… One idea is that that virulence factors were acquired in order to increase the fitness of fungi …