… was illuminated by the crystal structure of a ternary complex comprising FGF23, the FGFR1c
… heparin dodecasaccharide (hereafter, referred to as HS). The three resulting quaternary …

… The crystal structure of FGF401/FGFR4 was recently reported by our laboratory (PDB ID 6JPJ)
[57], … (B) Crystal structure of the FGF2:FGFR1:heparin ternary complex (PDB ID 1FQ9). The …

… role of 6O-sulfation in HS-oligosaccharides. The sulfation at this position accelerates the
formation of the ternary complex … compete with heparin and form a tripartite complex with FGF2 …

… Furthermore, the LMWH has no significant effect on the crystal structure and the amounts
of Ca and P in the calcium phosphate in the LMWH−FGF-2−calcium phosphate composite …

… In the crystal structure of a ternary FGF–FGFR–heparin complex, heparin is shown to interact
… Interestingly, the structure of the FGF21–βKlotho complex shows how βKlotho has evolved …

… heparin sulfates is the primary step in the formation of FGF-FGFR-heparin ternary complex
… is absolutely required for FGF signaling; characterizing the heparin-binding region of FGF is …

… resolved crystal structures of eFGF signaling complexes open a new door for structure-…
to lack of extracellular matrix retention via the heparin-binding domain (HBD) characteristic of …

… Structural features of the extracellular FGFR portion in complex with FGF2 and heparin,
as well as the intracellular portion, including the ATP binding pocket (yellow rectangles), as …

… crystal structure of the FGF2-FGFR-Heparin ternary complex shows that FGF2 activity
depends on the heparin-dependent formation of 2:2 FGF2-FGFR dimer complex (Beenken et al. , …

… how multiple interactions between heparin or HSPG with both FGF and FGFR mediate tight
… questions whether the crystal structure of the ternary FGF23-R1/sKLA/FGFR1c complex (17) …