A variant of human growth differentiation factor-9 that improves oocyte developmental competence

WA Stocker, KL Walton, D Richani, KL Chan… - Journal of Biological …, 2020 - ASBMB
… (BMP15) are oocyte-secreted members of the transforming growth factor-β (TGF-β) superfamily
( … Cumulin, an oocyte-secreted heterodimer of the transforming growth factor-β family, is a …

Transforming growth factor-β superfamily and interferon-τ in ovarian function and embryo development in female cattle: review of biology and application

JD Michael, G Campanile… - Reproduction, Fertility and …, 2020 - CSIRO Publishing
… The focus of this review is on the transforming growth factor-β (TGFB) superfamily and
interferon-τ (IFNT). These have been the subject of previous reviews (Knight and Glister 2003, …

Rewarding Conversation Between Oocyte and Cumulus Cells Directs the Process of Folliculogenesis

D DAYANIR, H Ruso, Z Kalem, T Gurgan… - Gazi Medical …, 2019 - avesis.gazi.edu.tr
… , GDF-9B), which are members of the family of Transforming Growth Factor - Beta (TGF-β), are
of … Cumulin, an oocyte-secreted heterodimer of the transforming growth factor-β family, is a …

Cumulin and FSH Cooperate to Regulate Inhibin B and Activin B Production by Human Granulosa-Lutein Cells In Vitro

D Richani, K Constance, S Lien, D Agapiou… - …, 2019 - academic.oup.com
… by the oocyte-secreted growth factors growth differentiation factor … growth factor-β family, is
a potent activator of granulosa cells … usage of transforming growth factor-beta family ligands in …

Oocyte-secreted factors synergize with FSH to promote aromatase expression in primary human cumulus cells

E Hobeika, M Armouti, H Kala, MA Fierro… - The Journal of …, 2019 - academic.oup.com
… as oocyte-secreted factors (OSFs) and IGFs. How these factors coordinate oocyte maturation
with GC differentiation and follicular growth … However, GDF9:BMP15 heterodimers have not …

Regulation of insulin-like growth factor 2 by oocyte-secreted factors in primary human granulosa cells

E Hobeika, M Armouti, MA Fierro… - The Journal of …, 2020 - academic.oup.com
… To determine the role of oocyte-secreted factors (OSFs) such as growth differentiation
factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) in IGF2 production by hGCs. …

Granulosa secreted factors improve the developmental competence of cumulus oocyte complexes from small antral follicles in sheep

S Rouhollahi Varnosfaderani, M Hajian, F Jafarpour… - PloS one, 2020 - journals.plos.org
Oocyte in vitro maturation can be improved by mimicking the intra-follicular environment.
Oocyte, cumulus cells, granulosa cells, and circulating factors act as meiotic regulators in …

[HTML][HTML] Oocyte competence biomarkers associated with oocyte maturation: a review

B Sirait, B Wiweko, AA Jusuf, D Iftitah… - Frontiers in cell and …, 2021 - frontiersin.org
… as oocyte secreted factors (OSF) that belong to the transforming growth factor-β (TGF-β)
family, growth … could prevail as heterodimers (GDF-9/BMP-15), later known as cumulin, which …

[PDF][PDF] Engineering oocyte-secreted factors to improve the treatment of female infertility

WA Stocker - researchbank.swinburne.edu.au
… The transforming growth factor-β (… cumulin, GDF9 and BMP15; which indicated that cumulin
contains two unique type I receptor binding epitopes, one on either side of its heterodimeric

Oocyte and cumulus cell cooperativity and metabolic plasticity under the direction of oocyte paracrine factors

D Richani, A Poljak, B Wang… - American Journal …, 2024 - journals.physiology.org
… In the current study, to be sure of treatment with cumulin per se, we prevented 103 heterodimer
… This study provides a detailed exploration of the mechanisms by which oocyte-secreted