… transcription (FIGLA and NOBOX), folliculogenesis (NR5A1, WT1, and FOXL2), transforming
growth factor-β … [10, 11] The GDF9/BMP15 heterodimer potently activates granulosa cells via …

… Members of the transforming growth factor-β (TGFB) family … , as is the case for cumulin,
another TGFB family member [24]. … INHBA and increase heterodimeric INHBAC which has a …

… ) are the largest subgroup of the Transforming Growth Factor β (TGFβ) superfamily, one of the
… Lastly, we describe a procedure for the production of artificial BMP heterodimeric signaling …

… similarly in other heteromeric signaling complexes of the TGF-β family (4, 99). In the mouse
ovary, BMP15/GDF9 heterodimers, also known as cumulin (2), signal through SMAD2/3 but …

… More importantly, BMP15 forms heterodimers with GDF9 at the proprotein stage. The
BMP15 variants in the pro-region may have different degrees of inclination regarding forming …

… oocytes and somatic cells by governing the release of oocyte-secreted factors (OSFs) 17 .
These … of GCs and a reduced secretion of oocyte-secreted factors such as GDF9 under SMG. …

… GDF9 is activated by forming a heterodimer called ‘cumulin’ with the related protein BMP15
[… production of BMP15 homodimers and the more active cumulin heterodimer (Fig. 1d). …

… occurring mutations in the oocyte secreted factors bone morphogenetic protein-15 and …
Cumulin, an Oocyte-secreted Heterodimer of the Transforming Growth Factor-β Family, is a …

… Oocyte secreted factors (OSFs) GDF9 and BMP15 are important … heterodimer Pro-Cumulin
activates SMAD2/3 and SMAD 1/5/8, and its efficiency in IVM systems over mature Cumulin …

… Oocyte expression of the Transforming Growth Factor beta (TGFβ) family member proteins …
to interact with each other, forming the heterodimer cumulin, an activator of cumulus cells that …