… They may act alone or form a heterodimer, known as Cumulin [69]. BMP15 mutations affect
the ovary in several ways, for example, impaired early folliculogenesis, increased dizygotic …

… Oocyte secreted factors (OSFs) GDF9 and BMP15 are important … heterodimer Pro-Cumulin
activates SMAD2/3 and SMAD 1/5/8, and its efficiency in IVM systems over mature Cumulin …

… Oocyte expression of the Transforming Growth Factor beta (TGFβ) family member proteins …
to interact with each other, forming the heterodimer cumulin, an activator of cumulus cells that …

… Oocyte-secreted growth differentiation factor 9 (GDF9) and … In conclusion, serum concentrations
of oocyte-secreted factors… utility of members of the transforming growth factor-β (TGF-β) …

… The oocyte secreted factors GDF-9 and BMP-15 have been shown to play a role in growth,
differentiation, and function of granulosa and theca cells in follicular development. Although …

… that are hypothesised to form a heterodimer called cumulin. Cumulin is a potent stimulator of
… Cumulin has significant effects on metabolic processes in both cumulus cells and oocytes, …

… by growth factors, such as epidermal growth factor (EGF) family members amphiregulin, …
clinic when they are ready to start a family using their cryopreserved oocytes or ovarian tissue. …

… by growth factors, such as epidermal growth factor (EGF) family members amphiregulin, …
clinic when they are ready to start a family using their cryopreserved oocytes or ovarian tissue. …

The collagen type I alpha 1 chain (COL1A1), as a major component of extracellular matrix,
plays a potential role in the growth and development of bovine follicles. However, its specific …

… [34] reported that AMH suppresses growth differentiation factor 9 (GDF9) and bone
morphogenetic protein 15 (BMP15) expression. GDP9 and BMP15 are oocyte-secreted factors and …