Curcumin activates the Nrf2 pathway and induces cellular protection against oxidative injury

M Ashrafizadeh, Z Ahmadi… - Current Molecular …, 2020 - ingentaconnect.com
Curcumin induces Nrf2 nuclear translocation and prevents glomerular hypertension,
hyperfiltration, oxidant stress, and the decrease in antioxidant enzymes in 5/6 nephrectomized rats. …

Curcumin reverses diabetic nephropathy in streptozotocin-induced diabetes in rats by inhibition of PKCβ/p66Shc axis and activation of FOXO-3a

JZ ALTamimi, NA AlFaris, AM Al-Farga… - The Journal of nutritional …, 2021 - Elsevier
… In conclusion, Curcumin prevents kidney damage in diabetic rats by activating Nrf2, inhibiting
Nf-κB… In addition, Curcumin induced the nuclear translocation of FOXO3a in melanoma and …

[HTML][HTML] Nrf2 regulation by curcumin: molecular aspects for therapeutic prospects

SH Shahcheraghi, F Salemi, N Peirovi, J Ayatollahi… - Molecules, 2021 - mdpi.com
prevented by curcumin mainly due to promoting the Nrf2 … found that curcumin induced the
nuclear translocation of Nrf2 in … autoregulation, proteinuria and hypertension. The protective …

[HTML][HTML] Protective role of Nrf2 in renal disease

M Guerrero-Hue, S Rayego-Mateos… - Antioxidants, 2020 - mdpi.com
… Moreover, the Nrf2 inducer curcumin improved the nephrotoxic … Sodium polysulfide induced
nuclear translocation of Nrf2 … upregulation of Nrf2 with proteinuria and high blood pressure. …

Role of curcumin in ameliorating hypertension and associated conditions: a mechanistic insight

P Joshi, S Joshi, DK Semwal, K Verma… - Molecular and Cellular …, 2022 - Springer
… and alters mitochondrial permeability which hinders respiratory chain reactions [… Nrf2 from
Keap1 and its translocation to the nucleus. Glomerular high blood pressure and hyperfiltration

Protective effects of curcumin and its analogues via the Nrf2 pathway in metabolic syndrome

S Rajabi, M Darroudi, K Naseri… - Current Medicinal …, 2024 - ingentaconnect.com
… of flavonoids li e curcumin in preventing metabolic diseases. … Due to the nuclear translocation
of Nrf2, hyperfiltration, renal … of the glomeruli, such as glomerular hypertension and hy…

[HTML][HTML] Oxidative stress and NRF2/KEAP1/ARE pathway in diabetic kidney disease (DKD): new perspectives

DM Tanase, EM Gosav, MI Anton, M Floria… - Biomolecules, 2022 - mdpi.com
… carbohydrate metabolism and prevent the development … blood pressure and total cholesterol
in DKD patients. The same authors also pointed out a drawback of this analysis; curcumin

The pivotal role of nuclear factor erythroid 2-related factor 2 in diabetes-induced endothelial dysfunction

A Karan, E Bhakkiyalakshmi, R Jayasuriya… - Pharmacological …, 2020 - Elsevier
… Renal hyperfiltration mainly occurs due to the dilation of … was induced by SFN mediated
nuclear translocation of Nrf2 [91]. … Curcumin (CUR) is a popular spice, turmeric used in Asian …

Filtering through the role of NRF2 in kidney disease

CJ Schmidlin, MB Dodson, DD Zhang - Archives of pharmacal research, 2020 - Springer
… of using NRF2 inducing compounds to alleviate ROS to prevent or … Upregulation of NRF2
with curcumin was shown to reduce … of glomerular hypertension (increased glomerular capillary …

[HTML][HTML] Anti-viral potential and modulation of Nrf2 by curcumin: pharmacological implications

M Rahban, M Habibi-Rezaei, M Mazaheri, L Saso… - Antioxidants, 2020 - mdpi.com
… are cured by curcumin, Nrf2 activation prevented glomerular hypertension, hyperfiltration,
and … Recent studies have indicated that curcumin could activate nuclear translocation of Nrf2