Bispecific antibodies enable synthetic agonistic receptor-transduced T cells for tumor immunotherapy

CH Karches, MR Benmebarek, ML Schmidbauer… - Clinical Cancer …, 2019 - AACR
… -LUC xenograft model, we could observe significant infiltration and persistence of E3 T cells
in the treated … expressing a SAR that can be targeted by the depleting monoclonal antibody

A novel EGFRvIII T-cell bispecific antibody for the treatment of glioblastoma

…, X Guardia-Reyes, L Fahrni, T Pöschinger… - Molecular Cancer …, 2022 - AACR
… of human GBM samples were digested with the Human Tumor … Three days after treatment,
we observed that CD3 T cells … of CD3 T cells expressing luciferase in U87MG xenografts on …

[HTML][HTML] Combination of T-cell bispecific antibodies with PD-L1 checkpoint inhibition elicits superior anti-tumor activity

J Sam, S Colombetti, T Fauti, A Roller, M Biehl… - Frontiers in …, 2020 - frontiersin.org
treatment increases the frequency of total intra-tumor T-cells, and … The anti-PD-L1 monoclonal
antibody used in the … ) bearing a human gastric adenocarcinoma xenograft tumor (MKN-…

[HTML][HTML] Potent ex vivo armed T cells using recombinant bispecific antibodies for adoptive immunotherapy with reduced cytokine release

JA Park, BH Santich, H Xu, LG Lum… - … of cancer, 2021 - ncbi.nlm.nih.gov
… multiple cancer cell lines and patient-derived xenograft mouse … (γδ) T cells were investigated
as unrelated alternative effector T … of T cells in the blood and tumors after γδ-EAT treatment

[HTML][HTML] A novel T cell-engaging bispecific antibody for treating mesothelin-positive solid tumors

A Yoon, S Lee, S Lee, S Lim, YY Park, E Song, DS Kim… - Biomolecules, 2020 - mdpi.com
… and produced regression of xenograft tumors with CD8+ T-cell … of circulating T cells. Thus,
MG1122-B may be useful for … monoclonal antibody, we used the mouse anti-human CD3ε …

[HTML][HTML] Targeting tumor vasculature to improve antitumor activity of T cells armed ex vivo with T cell engaging bispecific antibody

JA Park, M Espinosa-Cotton, H Guo… - … of Cancer, 2023 - ncbi.nlm.nih.gov
cancer cell line-derived xenografts (CDXs) or patient-derived … hCD45(+) T cells than tumors
treated with unarmed T cells as … is known to increase levels of plasma hVEGF in human tumor

Humanized mouse model for in vivo evaluation of bispecific antibody efficacy

LC Yao, JG Keck, D Cai - Cancer Research, 2022 - AACR
… EGFR bispecific T cell engager (EGFRXCD3 BiTE) using xenograft … with human CD34+ HSC
and have human T cells in … resistant to EGFR monoclonal antibody drug cetuximab despite …

Targeting T cells with tetravalent bispecific antibodies for the treatment of graft versus host disease

M Espinosa-Cotton, SS Hoseini, IC Miranda… - Blood …, 2024 - ashpublications.org
… To this end, several monoclonal antibodies have been … experiments using mice xenografted
with human leukemia, but 304 … T cells to GD2 421 pentasaccharide on human tumors using …

[HTML][HTML] Overcoming tumor heterogeneity by ex vivo arming of T cells using multiple bispecific antibodies

JA Park, NKV Cheung - Journal for Immunotherapy of Cancer, 2022 - ncbi.nlm.nih.gov
… on retargeting T cells has renewed hope for durable cancer cure. … and a few cancers with
high tumor mutational burden. … cancer cells were xenografted subcutaneously and treated

A novel targeted GPC3/CD3 bispecific antibody for the treatment hepatocellular carcinoma

L Yu, X Yang, N Huang, QL Lang, QL He… - Cancer Biology & …, 2020 - Taylor & Francis
… antigen receptor T cells and bispecific antibodies. However, … of bispecific antibody, we
removed the murine xenografts of … -GPC3 antibody are derived from monoclonal antibody L2K …