[HTML][HTML] Regulating the regulators: Is introduction of an antigen-specific approach in regulatory T cells the next step to treat autoimmunity?

I Janssens, N Cools - Cellular Immunology, 2020 - Elsevier
… to control immune responses, including regulation of self-tolerance by silencing self-reactive
T cells, and … or contact-dependent effector T cell suppression via Treg surface-bound TGF-β. …

Regulatory T cells: regulation of identity and function

P Grover, PN Goel, MI Greene - Frontiers in immunology, 2021 - frontiersin.org
… or immune homeostasis by eliminating the autoreactive T cells, … other T cell populations,
uncertainty in the molecular features of suppression, and difficulty in developing antigen-specific

Regulatory immune mechanisms beyond regulatory T cells

G Christoffersson, M von Herrath - Trends in immunology, 2019 - cell.com
… are the presence of autoreactive T cells and autoantibodies in the … cells other than Tregs,
such as non-antigen-specific CTLs, can take on regulatory tasks to suppress anti-self immune

Principles of regulatory T cell function

S Dikiy, AY Rudensky - Immunity, 2023 - cell.com
Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system
… system can be attributed to their ability to restrain all currently recognized major types of …

Counter-regulation of regulatory T cells by autoreactive CD8+ T cells in rheumatoid arthritis

I Cammarata, C Martire, A Citro, D Raimondo… - Journal of …, 2019 - Elsevier
… + T cells express a phenotype and gene profile of effector (eff) cells and, upon antigen-specific
suppression = (MFI CFSE-stained AE-CD8 + T cells with Tregs – CFSE-stained AE-CD8 + …

Antigen-specific T cells and autoimmunity

M Rojas, Y Acosta-Ampudia, LS Heuer, W Zang… - Journal of …, 2024 - Elsevier
… While therapies targeting broad T-cell suppression have … target and neutralize autoreactive
T cells through various … through the activation of antigen-specific regulatory T cells (Tregs). …

Boosting regulatory T cell function for the treatment of autoimmune diseases–That's only half the battle!

J Schlöder, F Shahneh, FJ Schneider… - Frontiers in …, 2022 - frontiersin.org
autoreactive T cells due to a reduced responsiveness of T … Apparently, antigen specific
Treg have a higher capability … in an antigen-specific manner and exert suppression largely by …

Re-programming autoreactive T cells into T-regulatory type 1 cells for the treatment of autoimmunity

P Solé, P Santamaria - Frontiers in Immunology, 2021 - frontiersin.org
… IL-10)-producing regulatory T cells (Tregs) are key to immuneantigen-specific IL-10-producing
CD4+ T cells in the memory … activation is antigen-specific, TR1-mediated suppression of …

[HTML][HTML] Forced Fox-P3 expression can improve the safety and antigen-specific function of engineered regulatory T cells

J McGovern, A Holler, S Thomas, HJ Stauss - Journal of Autoimmunity, 2022 - Elsevier
Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive
immune responses and central nervous system inflammation during active experimental …

Antigen-specific regulatory T cell therapy in autoimmune diseases and transplantation

C Selck, M Dominguez-Villar - Frontiers in immunology, 2021 - frontiersin.org
… could provide an additional approach to directly target autoreactive B cells in AID (93). …
In addition, interventions that preferentially inhibit pathogenic T cells over Treg cells could be …