[HTML][HTML] Structural aspects of chemical modifications in the MHC-restricted immunopeptidome; Implications for immune recognition
T Sandalova, BM Sala, A Achour - Frontiers in Chemistry, 2022 - frontiersin.org
… Most importantly these analyses provide essential … the impact of PTM peptides on stability of
MHC/peptide complexes… I alleles, and that form hydrogen bonds with peptide termini (Figure …
MHC/peptide complexes… I alleles, and that form hydrogen bonds with peptide termini (Figure …
[HTML][HTML] Dynamically driven allostery in MHC proteins: Peptide-dependent tuning of class I MHC global flexibility
… Crystallographic structures of TCR-peptide/MHC complexes have … existence of finer control
mechanisms influencing immunogenicity … subunit necessary for class I MHC complex stability. …
mechanisms influencing immunogenicity … subunit necessary for class I MHC complex stability. …
[HTML][HTML] Effects of HLA single chain trimer design on peptide presentation and stability
KAK Finton, PB Rupert, DJ Friend, A Dinca… - Frontiers in …, 2023 - frontiersin.org
… affect its use for basic and translational studies, we evaluated a set of engineered single-chain …
of 874 Å 2 including eight salt bridges and 17 hydrogen bonds (Supplementary Table 4). …
of 874 Å 2 including eight salt bridges and 17 hydrogen bonds (Supplementary Table 4). …
Cd4+ T-cell epitope prediction by combined analysis of antigen conformational flexibility and peptide-Mhcii binding affinity
T Charles, DL Moss, P Bhat, PW Moore… - Biochemistry, 2022 - ACS Publications
… to MHCII depends on hydrogen bonds to the peptide backbone. (… , and then the peptide-MHC
complexes are transported to … of conformational stability are essential for APL performance. …
complexes are transported to … of conformational stability are essential for APL performance. …
[HTML][HTML] HLA-DM catalytically enhances peptide dissociation by sensing peptide–MHC class II interactions throughout the peptide-binding cleft
E Reyes-Vargas, AP Barker, Z Zhou, X He… - Journal of Biological …, 2020 - ASBMB
… We show that the intrinsic stability of a pMHCII linearly … -presentation pathway is crucial for
immune surveillance as … a network of MHCII conserved hydrogen bonds with the peptide main …
immune surveillance as … a network of MHCII conserved hydrogen bonds with the peptide main …
[HTML][HTML] How peptide/MHC presence affects the dynamics of the LC13 T-cell receptor
JL Dominguez, B Knapp - Scientific Reports, 2019 - nature.com
… presenting cells is one of the most important mechanisms of … as alteration in the hydrogen
bond network around CDR3α of … to investigate the flexibility/stability of different TCR regions (…
bond network around CDR3α of … to investigate the flexibility/stability of different TCR regions (…
[HTML][HTML] At the cutting edge against cancer: a perspective on immunoproteasome and immune checkpoints modulation as a potential therapeutic intervention
GR Tundo, D Sbardella, F Oddone, AA Kudriaeva… - Cancers, 2021 - mdpi.com
… peptide MHC class I binding are essentially two: (1) the length of 8–9 amino acids and (2)
an anchor of basic … genes (generated by the intrinsic instability of cancer cells and hereafter …
an anchor of basic … genes (generated by the intrinsic instability of cancer cells and hereafter …
The Characteristics of Immunogenic Peptide: MHC Class i Complexes Presented During Viral Infection
MJ Witney - 2023 - search.proquest.com
… peptide:MHC Class I complexes (p:MHC-I) is a fundamental … likely provide an important
capacity to control infection when … p:MHC-I affinity and stability are fundamental to our ability to …
capacity to control infection when … p:MHC-I affinity and stability are fundamental to our ability to …
[HTML][HTML] Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus
… In theory, the stability of a covalent bond between TCR and … Our results demonstrate rebinding
is not necessary for T cell … , which encodes GFP under the control of an internal ribosomal …
is not necessary for T cell … , which encodes GFP under the control of an internal ribosomal …
The electrostatic landscape of MHC-peptide binding revealed using inception networks
… By analyzing this fundamental immunological process … to compute peptide binding and
stability, study the granularity … highly polymorphic family of peptide-MHC complexes to seek the …
stability, study the granularity … highly polymorphic family of peptide-MHC complexes to seek the …