[HTML][HTML] Cancer testis antigen Cyclin A1 harbors several HLA-A* 02: 01-restricted T cell epitopes, which are presented and recognized in vivo

AT Teck, S Urban, P Quass, A Nelde… - Cancer Immunology …, 2020 - Springer
… lysis of target cells due to peptide-specific lytic activity of cytotoxic TT cells, modern adoptive
T cell therapies are not dependent on the endogenous TCR repertoire of the patient but on …

Immune awakening revealed by peripheral T cell dynamics after one cycle of immunotherapy

S Valpione, E Galvani, J Tweedy, PA Mundra… - Nature cancer, 2020 - nature.com
… To study cytotoxic T cell turnover, we sequenced the TCR in t … with a model in which the
tumor is an open compartment with … patients, we observed a significant early T cell repertoire

Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer

…, A Harari, DE Speiser, A Mathis, D Gfeller… - Science …, 2021 - science.org
T cells in combination with CTLA-4 (Cytotoxic T-Lymphocyte … , tumor-specific cytotoxic CD4
T cells in patients with cancer. … Previous TCR repertoire analyses of CD4 T cells featuring …

Low-dose CDK4/6 inhibitors induce presentation of pathway specific MHC ligands as potential targets for cancer immunotherapy

…, T Korontsvit, ZEH Aretz, SS Mun, T Dao… - …, 2021 - Taylor & Francis
… if increased Cyclin D1 presentation in cells treated with CDK4/… immunopeptidome repertoire
after CDK4/6i treatment whereby … CD4 and CD8+ cytotoxic T cell responses in HLA matched …

γδ T-cell receptors derived from breast cancer–infiltrating T lymphocytes mediate antitumor reactivity

…, M Werner, K Heise, M Follo, T Straetemans… - Cancer immunology …, 2020 - AACR
… γδ T cells to induce regressions in advanced cancer patientscancer patients, we developed
the concept of TEGs (T cells … We also analyzed TCRδ repertoires in TIL sequencing data …

[HTML][HTML] T Cell Receptor Chain Centricity: The Phenomenon and Potential Applications in Cancer Immunotherapy

AA Kalinina, LM Khromykh, DB Kazansky - International Journal of …, 2023 - mdpi.com
… cognate infection, specific cytotoxic T lymphocytes (CTLs) in … of tumor-specific T cells
naturally occurring in a patient’s … naturally forming repertoire of memory T cells contains chain-…

Transient Depletion of CD4+ Cells Induces Remodeling of the TCR Repertoire in Gastrointestinal Cancer

…, K Shitara, M Shimomura, T Suzuki, T Nakatsura… - Cancer Immunology …, 2021 - AACR
… Through this blood–tumor overlapping repertoire analysis, … of the T-cell repertoire and
antitumor T-cell responses following … baseline repertoire of CD4 + and CD8 + T cells in patients in …

[HTML][HTML] KIR+ CD8+ T lymphocytes in cancer immunosurveillance and patient survival: gene expression profiling

L Gimeno, EM Serrano-López, JA Campillo… - Cancers, 2020 - mdpi.com
D) or HLA-C1 ligands. Figure S1 shows KIR+ CD8+ T cell repertoires breakdown for each
type of solid cancer… in the effector function of cytotoxic T cell. As previously described, and in …

Common gamma chain cytokines and CD8 T cells in cancer

M Shourian, JC Beltra, B Bourdin, H Decaluwe - Seminars in Immunology, 2019 - Elsevier
… blockade and adoptive cell therapy. Finally, we will … T cell immunity during cancer and
whether targeting these pathways may sustain an effective and durable T cell response in patients

Tumor-infiltrating T cell receptor-beta repertoires are linked to the risk of late chemoradiation-induced temporal lobe necrosis in locally advanced nasopharyngeal …

LF Wu, YL Chung - International Journal of Radiation Oncology* Biology …, 2019 - Elsevier
patients with intracranial invasion and showed that some specific intratumoral T cell receptor-beta
repertoire … post-chemoradiotherapy neutrophil-to-lymphocyte ratios were linked to TLN …