[PDF][PDF] Cadmium induces migration of colon cancer cells: roles of reactive oxygen species, P38 and cyclooxygenase-2

S Naji, K Issa, A Eid, R Iratni, AH Eid - Cell Physiol Biochem, 2019 - researchgate.net
… Because Cd was previously shown to induce ROS accumulation in various cells, we therefore
investigated its effect on ROS production in HT-29 colon cancer cells. As shown in Fig. 2C …

[PDF][PDF] Atorvastatin inhibits proliferation and promotes apoptosis of colon cancer cells via COX-2/PGE2/β-Catenin Pathway

S Cai, Z Gao - J. Buon, 2021 - jbuon.com
… Purpose: To explore the effects of atorvastatin (ATST) on the proliferation and apoptosis
of colon cancer cells through the cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2)/βcatenin …

Interplay between cyclooxygenase2 and microRNAs in cancer

Z Gong, W Huang, B Wang… - Molecular …, 2021 - spandidos-publications.com
… play vital roles in regulating cancer development and progression. … in different types of cancer.
Understanding the regulatory … Colorectal cancer (CRC) is one of the most common human …

Cyclooxygenase-2-Prostaglandin E2 pathway: A key player in tumor-associated immune cells

K Jin, C Qian, J Lin, B Liu - Frontiers in oncology, 2023 - frontiersin.org
… the risk of developing colon cancer and resulted in reduced multiplicity of distal colon tumors
as … the development of colon cancer (21). Taken together, PGE2 is essential in the growth of …

Gut-restricted selective cyclooxygenase-2 (COX-2) inhibitors for chemoprevention of colorectal cancer

Z Zhang, A Ghosh, PJ Connolly, P King… - Journal of Medicinal …, 2021 - ACS Publications
Colorectal cancer (CRC) is the third leading cause of cancer-related death in both men
and women in the United States and also one of the most preventable malignancies. (1,2) …

Cyclooxygenase inhibitors and cancer: the missing pieces

C Patrono - Journal of Pharmacology and Experimental …, 2023 - ASPET
… trials of low-dose aspirin and selective cyclooxygenase-2 inhibitors. A single placebo-… term
colorectal cancer prevention in patients with the Lynch syndrome. The sequential involvement

Cyclooxygenases and prostaglandins in tumor immunology and microenvironment of gastrointestinal cancer

D Wang, CS Cabalag, NJ Clemons, RN DuBois - Gastroenterology, 2021 - Elsevier
… of the cyclooxygenase-2–prostaglandin E 2 pathway on gastrointestinal cancer development.
… For example, colorectal cancer (CRC) is the fourth most common malignancy and the third …

[HTML][HTML] Combined chemotherapy with cyclooxygenase-2 (COX-2) inhibitors in treating human cancers: Recent advancement

S Li, M Jiang, L Wang, S Yu - Biomedicine & Pharmacotherapy, 2020 - Elsevier
colorectal cancer and showed reduction of colon cancer stem cell subpopulation and tumor
growth, thus confirming their impairment of the EGFR/RAS/FOXM1/β-catenin signaling axis. …

[HTML][HTML] Inhibition of COX-2 impairs colon cancer liver metastasis through reduced stromal cell reaction

A Herrero, A Benedicto, I Romayor… - Biomolecules & …, 2021 - ncbi.nlm.nih.gov
… We analyzed the in vitro proliferative and secretory responses of murine C26 colorectal
cancer (CRC) cells to soluble ICAM-1 (sICAM-1), cultured alone or with LSECs, and their effect …

Role of anti-inflammatory drugs in the colorectal cancer

O Sada, K Ahmed, A Jeldo, M Shafi - Hospital pharmacy, 2020 - journals.sagepub.com
… as a molecular marker and a potential therapeutic target is cyclooxygenase-2 (Cox-2) in
various cancers. The main function of Cox is to synthesize prostaglandins (PGs) from …