lncRNA-PACER upregulates COX-2 and PGE2 through the NF-κB pathway to promote the proliferation and invasion of colorectal-cancer cells
P Sun, JC Quan, S Wang, M Zhuang, Z Liu… - Gastroenterology …, 2021 - academic.oup.com
… p50-associated cyclooxygenase-2 extragenic RNA (PACER) … upstream of the promoter region
of cyclooxygenase-2 (COX-2)… However, the role of this lncRNA in colorectal cancer (CRC) …
of cyclooxygenase-2 (COX-2)… However, the role of this lncRNA in colorectal cancer (CRC) …
Inhibition of COX-2 and 5-LOX regulates the progression of colorectal cancer by promoting PTEN and suppressing PI3K/AKT pathway
J Chang, N Tang, Q Fang, K Zhu, L Liu, X Xiong… - Biochemical and …, 2019 - Elsevier
… target for colorectal cancer therapy. In short, COX-2 or 5-LOX deletion and its inhibitors …
suppressed cell and adenoma progression through PI3K/AKT pathway in colorectal cancer. …
suppressed cell and adenoma progression through PI3K/AKT pathway in colorectal cancer. …
Understanding the interplay between COX-2 and hTERT in colorectal cancer using a multi-omics analysis
GD Ayiomamitis, G Notas, T Vasilakaki, A Tsavari… - Cancers, 2019 - mdpi.com
… Conclusions: Our data support that COX-2 is involved in the early stages of colorectal cancer
development, initially affecting the tumor’s stromal microenvironment, and, subsequently, …
development, initially affecting the tumor’s stromal microenvironment, and, subsequently, …
Sulforaphane, a chemopreventive compound, inhibits cyclooxygenase-2 and microsomal prostaglandin e synthase-1 expression in human HT-29 colon cancer cells
… To explore the possible role of SFN in tumor progression, we evaluated its potential to
modify the motility/wound-healing activity of HT-29 cells. In the scratch test, we observed a …
modify the motility/wound-healing activity of HT-29 cells. In the scratch test, we observed a …
[HTML][HTML] Colorectal carcinoma, cyclooxygenases, and Cox inhibitors
V Ganduri, K Rajasekaran, S Duraiyarasan… - Cureus, 2022 - ncbi.nlm.nih.gov
… been associated with the development of CRC [6]. Colorectal malignancies develop from
their benign precursors via two major pathways of the adenoma-carcinoma sequence or the …
their benign precursors via two major pathways of the adenoma-carcinoma sequence or the …
[PDF][PDF] The inflammatory profile of the tumor microenvironment, orchestrated by cyclooxygenase-2, promotes epithelial-mesenchymal transition
F Gómez-Valenzuela, E Escobar… - Frontiers in …, 2021 - frontiersin.org
… profile in various types of solid malignant tumors such as gastric cancer (57), colorectal
cancer (58), hepatocellular carcinoma (59), melanoma (60), pancreatic cancer (36), endometrial …
cancer (58), hepatocellular carcinoma (59), melanoma (60), pancreatic cancer (36), endometrial …
Expression of long non-coding RNA CCHE1 in colorectal carcinoma: correlations with clinicopathological features and ERK/COX-2 pathway
… This study included 60 patients presenting with primary colorectal carcinoma (CRC) admitted
to the General Surgery Department of Tanta University Hospital, during the period between …
to the General Surgery Department of Tanta University Hospital, during the period between …
Clinical value of detecting IQGAP3, B7-H4 and cyclooxygenase-2 in the diagnosis and prognostic evaluation of colorectal cancer
H Cao, Q Wang, Z Gao, X Xu, Q Lu, Y Wu - Cancer cell international, 2019 - Springer
… B7-H4 and cyclooxygenase-2 (COX-2) in patients with colorectal cancer (CRC) and in
healthy individuals, aiming to evaluate the diagnostic and prognostic value of IQGAP3 for CRC. …
healthy individuals, aiming to evaluate the diagnostic and prognostic value of IQGAP3 for CRC. …
COX-2 gene rs689466 polymorphism is associated with increased risk of colorectal cancer among Caucasians: a meta-analysis
YC Zhang, H Zhao, C Chen, MA Ali - World Journal of Surgical Oncology, 2020 - Springer
… Several studies have reported the Cyclooxygenase 2 (COX-2) rs689466 polymorphism as
a susceptibility locus of colorectal cancer (CRC), but their findings are inconsistent. Thus, this …
a susceptibility locus of colorectal cancer (CRC), but their findings are inconsistent. Thus, this …
Vitamin D, linoleic acid, arachidonic acid and COX-2 in colorectal cancer patients in relation to disease stage, tumour localisation and disease progression
B Joanna, B Jolanta, G Agnieszka, HZ Diana… - Arab Journal of …, 2019 - Elsevier
… by cyclooxygenase-2. In colorectal cancer patients overexpression of COX-2 has been
detected and it is suggested that it may be a predictor of poor outcome for these patients [22]. …
detected and it is suggested that it may be a predictor of poor outcome for these patients [22]. …