… Colon cancer (CC) is tightly associated with chronic inflammation [3]. … via the cyclooxygenase
2 (COX-2) pathway, play a crucial role in generating the inflammatory response, and their …

… The signaling of cyclooxygenase 2-prostaglandin E 2 -prostaglandin E 2 receptors (COX-2-PGE …
COX inhibitory drugs show protective effects in colorectal cancer and breast cancer [13]. …

… malignancies worldwide. The main risk factors for CRC are family history of colon or rectal
cancer… nonpolyposis, and chronic inflammatory bowel diseases (ulcerative colitis and Crohn's …

… It has been found that over-activation of cyclooxygenase 2 (COX-2), followed by the … cancer
therapy. This review will explore the role of EP4 receptor in the development of colon cancer …

Endometriosis (EMS) is the most common gynecological disease in women of reproductive
age, and it is associated with chronic pelvic pain, dyspareunia and infertility. As a …

… Darbufelone (10) also showed anticancer activity in the colorectal cancer (CRC) cell line,
accompanied by dual LOX/COX-2 inhibition [27]. Similarly, compound 11 also exhibited dual …

… Mechanistically, DCLK1 bound and phosphorylated XRCC5, which in turn transcriptionally
activated cyclooxygenase-2 expression and enhanced prostaglandin E 2 production; these …

… , such as colorectal adenomas and aberrant crypt foci. Some promising agents have …
developed for the prevention of CRC. The chemopreventive effect of selective cyclooxygenase 2 …

… The expression of cyclooxygenase-2(COX-2) and prostaglandin E2 (PGE2) is also … , it needs
to be underlined that the results of the research on opioids’ role in cancer development and …

… his colleagues find that a relatively low dose of NSAIDs (aspirin) for a long time decreases
the risks of developing colon cancers … : Breast cancer cell cyclooxygenase2 expression alters …