… to various activating or inhibitory stimuli. Arachidonic acid is … primary haemostasis and
atherothrombosis is demonstrated … low-dose aspirin, a selective inhibitor of platelet COX-1. The …

… [http://dx.doi.org/10.1021/bi900999z] [PMID: 19603831] [41] Sharma, NP; Dong, L.; Yuan,
C.; Noon, KR; Smith, WL Asymmetric acetylation of the cyclooxygenase-2 homodimer by …

… the pool of circulating monocytes in a cyclooxygenase-2 (COX-2) … in acute and unstable
atherothrombosis, implying that … Thus, if COX-2 expression can be inhibited effectively, it will …

Cyclo-oxygenase (COX) inhibitors are among the most … evidence that COX inhibition
induces vasodilation and is … regarding the cardiotoxicity of COX inhibitors. While studies to …

… is associated with cyclooxygenase-2 expression in discrete … implicated in the reduced
atherothrombosis observed in mouse … with unintentional cyclooxygenase-2 inhibition (61) and the …

… protein expression … inhibitor-1 (PAI-1), cyclooxygenase-2 (COX-2), and VE-cadherin, which
are altered by various factors in endothelial tissue. VCAM-1, PAI-1, and COX-2 expression …

… In endothelial activation assays, there were no biologically significant changes in the
expression level of 7 potential endothelial injury markers for any of our COX inhibitor compounds …

… , assessing the cardiovascular risk of cyclooxygenase-2 selective inhibitors. It is a qualitative
… between selective or non-COX inhibition. The selective inhibition of COX-2 arose with the …

… platelet aggregation (51), and our finding that a selective DP1 antagonist inhibited 15R-PGD
2 –induced aggregation suggested DP1 as a major target of 15R-PGD 2 in platelets. This …

… Aspirin modifies cyclooxygenase-2 (COX2) by acetylation in Ser 530 . This modification, …
the expression of adhesion molecules on human leukocytes in whole blood and to inhibit …