Polydatin protects against lipopolysaccharide-induced endothelial barrier disruption via SIRT3 activation

J Wu, Z Deng, M Sun, W Zhang, Y Yang, Z Zeng… - Laboratory …, 2020 - nature.com
… enhanced SIRT3-mediated deacetylation of SOD2 and cyclophilin D (CypD), thus suppressing
… 4a–d). These results indicate that PD attenuates LPS-elicited vascular barrier disruption

Proximal tubule cyclophilin D mediates kidney fibrogenesis in obstructive nephropathy

HS Jang, MR Noh, L Ha, J Kim… - American Journal of …, 2021 - journals.physiology.org
attenuates the lipopolysaccharide-induced inflammatory … of CypD in the inflammatory
response of macrophages to acute … autophagy and microtubule disruption. Biochim Biophys Acta …

[HTML][HTML] The role of cyclophilins in inflammatory bowel disease and colorectal cancer

L Liang, R Lin, Y Xie, H Lin, F Shao… - International Journal of …, 2021 - ncbi.nlm.nih.gov
inflammatory response by activating NF-κB 137 . This indicates the important significance of
CD147 in inflammatory … targeted deletion of CypD attenuated the mitochondrial necrosis of …

[HTML][HTML] Mitochondrial dysfunction precedes hippocampal IL-1β transcription and cognitive impairments after low-dose lipopolysaccharide injection in aged mice

Y Lee, X Ju, J Cui, T Zhang, B Hong, YH Kim, Y Ko… - Heliyon, 2024 - cell.com
Acute cognitive impairments termed delirium often occur after inflammatory insults in elderly
patients. While previous preclinical studies suggest mitochondria as a target for reducing …

[HTML][HTML] Gryllus bimaculatus Extract Protects against Lipopolysaccharide-Derived Inflammatory Response in Human Colon Epithelial Caco-2 Cells

K Kim, EY Park, DJ Baek, SE Jang, YS Oh - Insects, 2021 - mdpi.com
… cells from lipopolysaccharide-induced impaired barrier … were normalized to the abundance
of cyclophilin mRNA [23]. … been frequently found to attenuate inflammation. The mitochondrial …

[HTML][HTML] Indomethacin augments lipopolysaccharide-induced expression of inflammatory molecules in the mouse brain

MY Mohamed, W Masocha - PeerJ, 2020 - peerj.com
… Thus, the current data correlate with the previous reported findings that LPS-induced
proinflammatory cytokines and Nos2 expression, which elicit an inflammatory response in the brain. …

[HTML][HTML] … dichotoma larval extract attenuates intestinal barrier disruption by altering inflammatory response and tight junction proteins in lipopolysaccharide-induced …

K Kim, GD Bae, EY Park, DJ Baek, CY Kim… - Biochemical and …, 2020 - Elsevier
… Penetration of luminal noxious agents via disrupted TJs induces perturbation of the mucosal
immune system and inflammation that contributes to the progression of intestinal disease. …

[HTML][HTML] Capsaicin attenuates lipopolysaccharide-induced inflammation and barrier dysfunction in intestinal porcine epithelial cell line-J2

X Zhao, B Dong, M Friesen, S Liu, C Zhu… - Frontiers in …, 2021 - frontiersin.org
… This study investigated the effects of capsaicin on the gut inflammatory response,
intestinal epithelial integrity, and gene expression level of nutrient transporters in a model of …

Eugenol attenuates inflammatory response and enhances barrier function during lipopolysaccharide-induced inflammation in the porcine intestinal epithelial cells

Q Hui, E Ammeter, S Liu, R Yang, P Lu… - Journal of Animal …, 2020 - academic.oup.com
… effect of eugenol on inflammatory responses and gut barrier … attenuated inflammatory
responses and enhanced selectively permeable barrier function during LPS-induced inflammation

Recruitment of pro-IL-1α to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation

J Dagvadorj, K Mikulska-Ruminska… - Proceedings of the …, 2021 - National Acad Sciences
… of the innate immune response to infectious agents, but its … not due to an artifact of genomic
disruption in the knockout mice, or a … membrane may interrupt and attenuate the CL-LC3b–…