… of the lytic capacity of CD4 + T-cells from patients with HIV … death was abrogated by the
inhibitor of perforin-mediated … selective pressure, inducing escape mutations during their control […

… were lysed by adding 40 μl of working lysis … mutation and presumably diminished recognition
was associated with preserved CTL function. Consistent with our results, epitope mutation …

… impairing responsiveness to CTL-derived lytic signals. … that CMA inhibits nef alleles isolated
from diverse clades of HIV, … pressure to generate CTL-escape mutants prior to the initiation of …

… [2, 3], the emergence of virus CTL escape mutants[4, 5], the … + T cells were determined
using a more stringent viability cutoff … HIV-1 DNA was calculated by using serial dilutions lysed …

… BCL-2 is a master regulator of apoptosis that can inhibit both the perforin/granzyme B and
FasL/Fas … We observed significant losses in viable CD4 + T cells with increasing peptide …

… internal deletions and lethal genetic mutations. As these defective proviruses … that cytotoxic
T lymphocytes (CTLs) may recognize cells … assay (RIPA) lysis buffer containing 50 mM Tris⋅…

… by CTL escape mutations that typically accumulate within HIV … signals delivered by activating
and inhibitory receptors [41]. … HIV and up-regulate NKG2DL while preserving cell viability in …

… with combinations of multiple activating and inhibitory KIRs can be … NK cells are able to lyse
HIV-infected target cells either … mutations were shown for MCMV infection in mouse and HIV …

… HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and
peculiar cytotoxic T lymphocyte … (F) Summary of mutations and escape from CD8 + T cell …

… is feasible to clear host cells harboring replication-competent … of memory T cells, we tested
whether inhibition of autophagy … The cells were lysed in lysis buffer containing 50 mm HEPES, …