… Intracellularly, DAMPs are hidden from view of the innate immune system. After tissue injury,
… insults, they are released extracellularly to activate the immune system and resultant pro-…

… In the classical concept of immune recognition, DAMPs would in fact … activate innate immunity
and induce an inflammatory response regardless whether they are triggered by infection or …

… an exaggerated inflammatory response of innate immunity (106). … In this review, we discuss
several sepsis-induced DAMPs … In sepsis, excessive activation of these pathways leads to the …

… (DAMPs) … activation of residential innate immune cells (AECs, AMs, etc.) inducing the
neutrophil infiltration into the lungs. Toll-like receptor 4 (TLR4) activation induced immune response …

… -associate molecular patterns (DAMPs; released and/expressed by damaged/killed host
cells). Upon recognition of MAMPs and DAMPs, TLRs activate downstream signaling pathways …

… by triggering inflammation and activating coagulation, respectively. Therefore, the axis of
infection, immune response, immune cell death, DAMPs … of a local infection to sepsis (Figure 1). …

… (DAMPs) and … innate immune response is triggered promptly upon the invasion of a foreign
body or antigen. In the case of a gram-negative bacterial infection, one PRR that is activated …

… or antibodies ameliorate the sepsis course and lead to … involvement due to innate immune
system activation. Burns and … hyperactivation of the innate immune system could improve the …

… , they enable the innate immune system to monitor both … and DAMPs by PRRs is the
transcriptional activation of genes … resulting activation of caspase-11 occur during infection not …

… TMEM173, a hub of the innate immune signaling network) and high … DAMP). This mini-review
will discuss the regulation and function of inflammasome-dependent coagulation activation …