… to chloroquine and pyrimethamine but relatively sensitive to … and used for in vitro drug
assay and genotyping [13]. Frozen … first ACT introduced, but its efficacy steadily declined in the …

… Pyrimethamine and other antifolates such as proguanil (via its metabolite cycloguanil) and
trimethoprim target P… those that rely on the antifolate drug sulfadoxine-pyrimethamine (SP). In …

… isolates from Gabon correlate with in vitro activity of pyrimethamine and cycloguanil, but
not … genes and age related in vivo sulfadoxine-pyrimethamine resistance in malaria-infected …

… dhfr mutant with a double dhps mutant is a useful predictor of clinical SP treatment failure and
results in limited efficacy … in infants with sulfadoxine-pyrimethamine (SP-IPTi) should not be …

… biomarkers and therapeutic efficacy studies in malaria endemic … resistance to
sulfadoxine-pyrimethamine (SP) [26,39]. … -phenyl side chain such as pyrimethamine and …

… used in combination with sulfadoxine-pyrimethamine (750 mg … trial that involved children
of Kenya, Senegal and Gabon, … drugs pyrimethamine and cycloguanil. Studies have shown …

… of clinical SP treatment failure and results in limited efficacy of SP-… with sulfadoxinepyrimethamine
(SP-IPTi) should not be … of Plasmodium falciparum to sulphadoxine/pyrimethamine in …

… sulfadoxine-pyrimethamine TES therapeutic efficacy studies … report from Cambodia of
Plasmodium falciparum parasite with … can also represent genotypes arising de novo but not being …

… an active metabolite called cycloguanil pamoate. Mechanism of … Pyrimethamine and related
compounds inhibit the step … action, and widespread use of sulfadoxine/pyrimethamine (SP) …