… type I interferon signaling. Thus, DNA damage-dependent signaling rather than type I …
AGS is an early-onset childhood neuroinflammatory disorder that mimics congenital viral …

… dysfunction and DNA oxidation, followed by activation of the … various SASP mediators, resulting
in paracrine signalling and … leading to DNA damage in the human central nervous system …

… by which DNA damage may mediate neuronal dysfunction. … that their locations are likely
major mediators of their toxicity. As … that DNA damage can also evoke type-I interferon signaling …

… DNA damage and type I interferons (IFNs) contribute to … TBI increased expression of
proinflammatory mediators in the … to implicate IFN-β in the development of neurological …

… in the maintenance of immune responses in the brain. The … stimulate TBK1 to mediate an
interferon response. Whereas STING … DNA, leading to a greater susceptibility to DNA damage. …

… Released mtDNA can mediate inflammatory responses … in the nuclear DNA damage response
(as reviewed in [12]). When … Here, we focus on major depressive disorder as we believe it …

… and TRIF signaling cascades. (B) The main functional adaptations in microglia upon IFN-γR
and … Paired IFN-γR signaling (priming) and TLR signaling can result in exaggerated immune …

… causally related to neuronal loss and synaptic damage is still … be an inflammatory amplification
signal that promotes activation … mediator from immune cells to neurons exacerbating their …

… signaling pathways that recognize and repair DNA damage, and … [2], consisting of sensors,
mediators, transducers, and effectors, … DNA damage is a result of dysfunction of DNA repair …

… IFN-α and IFN-β are two major family members of type-I IFNs … JAK-STAT signaling pathways
appears to mediate the many … AGS) is a genetic inflammatory disorder that affects the brain (…