DNA methylation and regulation of gene expression: Guardian of our health

GA Dhar, S Saha, P Mitra, R Nag Chaudhuri - The Nucleus, 2021 - Springer
… , the DNA methylation pattern in the genome undergoes … result of regulated balance between
de novo DNA methylation and … DNA methylation pattern that fine tunes tissue-specific gene

Enhancer DNA methylation: implications for gene regulation

A Angeloni, O Bogdanovic - Essays in biochemistry, 2019 - portlandpress.com
DNA methylation involves the addition of a methyl group to the fifth carbon of the pyrimidine
cytosine ring (5-methylcytosine, 5mC). 5mC is widespread in vertebrate genomes where it is …

Prokaryotic DNA methylation and its functional roles

HJ Seong, SW Han, WJ Sul - Journal of Microbiology, 2021 - Springer
… cellular events regulated by DNA methylation in prokaryotes, … regulating gene expression
or by modulating the expression … , and through this, methylation signals might be used to …

DNA methylation: shared and divergent features across eukaryotes

RJ Schmitz, ZA Lewis, MG Goll - Trends in Genetics, 2019 - cell.com
… understanding of DNA methylation profiles and functions in different eukaryotic lineages. …
Recruitment of de novo cytosine methyltransferases is regulated by small RNAs and/or specific …

DNA methylation-free Arabidopsis reveals crucial roles of DNA methylation in regulating gene expression and development

L He, H Huang, M Bradai, C Zhao, Y You, J Ma… - Nature …, 2022 - nature.com
… We found that the EdU signal, a proxy for DNA replication and cell division, is dramatically
decreased in met1-9, and is virtually undetectable in mddcc (Fig. 6b), demonstrating that CG …

[HTML][HTML] Cellular response to endogenous DNA damage: DNA base modifications in gene expression regulation

DL Bordin, L Lirussi, H Nilsen - DNA repair, 2021 - Elsevier
… a program of regulatory events orchestrated by cellular signal transduction pathways that …
constitutes an active DNA demethylation pathway to reverse DNA methylation and maintain …

The diverse roles of DNA methylation in mammalian development and disease

MVC Greenberg, D Bourc'his - Nature reviews Molecular cell biology, 2019 - nature.com
… our knowledge of DNA methylation dynamics and heterogeneity … genetic analyses, it is
increasingly apparent that regulation … that DNA methylation affects splicing and gene expression, …

[HTML][HTML] Anything but ordinary–emerging splicing mechanisms in eukaryotic gene regulation

NH Gehring, JY Roignant - Trends in Genetics, 2021 - cell.com
… of splicing regulation are well … the regulation of gene expression. In this review, we summarize
the current principles of splicing regulation, including the impact of cis and trans regulatory

Evolution of DNA methylome diversity in eukaryotes

A de Mendoza, R Lister, O Bogdanovic - Journal of Molecular Biology, 2020 - Elsevier
… Despite DNA methylation being central to eukaryotic … been associated with constitutive gene
expression, with roles in … might not be directly associated with gene regulation. In contrast, …

DNA methylation methods: Global DNA methylation and methylomic analyses

S Li, TO Tollefsbol - Methods, 2021 - Elsevier
DNA methylation of promoters and distal regulatory regions control gene expression [2]. …
However, TLC fails to yield a signal of 5hmC with genomic DNA extracted from cancer cells and …