… and are derepressed in Dnmt triple-knockout mouse ESCs 117 , DNMT1-depleted human
fibroblasts 118 , Dnmt3B-mutant mouse embryos 27,119 and human diseases linked with …

… asthma and chronic obstructive pulmonary disease (COPD). Emerging … , DNA methylation
(DNAm), and that these changes might in turn influence inflammation, disease development, …

… - and histone-modifying enzymes are often mutated in overlapping human diseases. Here, …
mutations in DNA methylation modifiers are associated with human developmental disorders (…

… is also associated with neurological diseases, immunological diseases, atherosclerosis, …
discuss DNA hypermethylation in disease and its interrelationships with normal development as …

… DNA methylation, histone … human diseases. Recent evidence suggests that also epigenetic
modifications of the mitochondrial genome could contribute to the etiology of human diseases…

… the next section will examine recent evidence for AP in human disease. … human disease.
The criteria used was as follows, variant(s) needed to be significantly associated with a disease, …

… basic function and distribution of DNA methylation, evaluate its effects … DNA methylation
modifications identified in the most important cell types related to several autoimmune diseases …

… DNA methylation as an objective molecular diagnostic biomarker that can be reliably detected
and analyzed from archival human … both somatically acquired DNA methylation changes, …

… development, learning, memory, and disease in the human brain. Here we have elucidated
DNA methylation changes during recent human … trajectories of DNA methylation in cell-type …

… strongly linked to common diseases or occurring in response to various environmental
factors. DNA methylation based clocks are proposed as biomarkers of early disease risk as well …